Cellosaurus cell line HONE-1/CPT30R (CVCL

Cross-references
Cell line name	HONE-1/CPT30R
Synonyms	CPT30R
Accession	CVCL_M596
Resource Identification Initiative	To cite this cell line use: HONE-1/CPT30R (RRID:CVCL_M596)
Comments	Problematic cell line: Parent cell line (HONE-1) seems to bear part of the HeLa genomic sequence and may be a derivative of HeLa and another cell of unknown origin. Characteristics: Partial revertant of the CPT30 camptothecin-resistant subline. Selected for resistance to: ChEBI; CHEBI:27656; Camptothecin (CPT).
Sequence variations	Mutation; HGNC; 11986; TOP1; Simple; p.Glu418Lys (c.1252G>A); ClinVar=VCV000016774; Zygosity=Unspecified (PubMed=12097280).
Disease	Nasopharyngeal carcinoma (NCIt: C3871) Nasopharyngeal carcinoma (ORDO: Orphanet_150)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_M595 (HONE-1/CPT30)
Sex of cell	Male
Category	Cancer cell line
Publications	PubMed=12097280 Chang J.-Y., Liu J.-F., Juang S.-H., Liu T.-W., Chen L.-T. Novel mutation of topoisomerase I in rendering cells resistant to camptothecin. Cancer Res. 62:3716-3721(2002)
Cell line databases/resources	cancercelllines; CVCL_M596
Encyclopedic resources	Wikidata; Q54890149
Entry history
Entry creation	05-Nov-2013
Last entry update	05-Oct-2023
Version number	12