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Cellosaurus CRMM-2 (CVCL_M594)

[Text version]
Cell line name CRMM-2
Synonyms CRMM2; Conjunctival Recurrent Malignant Melanoma-2
Accession CVCL_M594
Resource Identification Initiative To cite this cell line use: CRMM-2 (RRID:CVCL_M594)
Comments Characteristics: Can form 3D spheroids (PubMed=32545782).
Doubling time: ~60 hours (Note=At passages 19 to 30) (PubMed=15993408).
Derived from site: In situ; Eye, bulbar conjunctiva; UBERON=UBERON_0010306.
Sequence variations
Disease Conjunctival melanoma (NCIt: C4550)
Conjunctival malignant melanoma (ORDO: Orphanet_617910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=25722211

Markers:
AmelogeninX,Y
CSF1PO12
D2S133817,23
D3S135815
D5S81811
D7S8208,11
D8S117912,14
D13S3178,11
D16S5399,13
D18S5114,17
D19S43313,14
D21S1128,31.2
FGA24
TH017,9.3
TPOX8
vWA16

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Publications

PubMed=15993408; DOI=10.1016/j.exer.2005.04.018
Nareyeck G., Wuestemeyer H., von der Haar D., Anastassiou G.
Establishment of two cell lines derived from conjunctival melanomas.
Exp. Eye Res. 81:361-362(2005)

PubMed=22275346; DOI=10.1136/bjophthalmol-2011-300686
Westekemper H., Freistuehler M., Anastassiou G., Nareyeck G., Bornfeld N., Steuhl K.-P., Scheulen M.E., Hilger R.A.
Chemosensitivity of conjunctival melanoma cell lines to single chemotherapeutic agents and combinations.
Br. J. Ophthalmol. 96:591-596(2012)

PubMed=25722211; DOI=10.1167/iovs.14-15239
de Waard N.E., Cao J.-F., McGuire S.P., Kolovou P.E., Jordanova E.S., Ksander B.R., Jager M.J.
A murine model for metastatic conjunctival melanoma.
Invest. Ophthalmol. Vis. Sci. 56:2325-2333(2015)

PubMed=28903377; DOI=10.18632/oncotarget.18039; PMCID=PMC5589616
Cao J.-F., Brouwer N.J., Richards K.E., Marinkovic M., van Duinen S., Hurkmans D., Verdegaal E.M.E., Jordanova E.S., Jager M.J.
PD-L1/PD-1 expression and tumor-infiltrating lymphocytes in conjunctival melanoma.
Oncotarget 8:54722-54734(2017)

PubMed=32545782; DOI=10.3390/biomedicines8060158; PMCID=PMC7344416
Fiorentzis M., Katopodis P., Kalirai H., Seitz B., Viestenz A., Coupland S.E.
Image analysis of 3D conjunctival melanoma cell cultures following electrochemotherapy.
Biomedicines 8:158.1-158.13(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_M594
Encyclopedic resources Wikidata; Q54814504
Polymorphism and mutation databases Cosmic; 2639618
Entry history
Entry creation05-Nov-2013
Last entry update19-Dec-2024
Version number14