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Cellosaurus ALMC-2 (CVCL_M526)

[Text version]
Cell line name ALMC-2
Synonyms ALMC2
Accession CVCL_M526
Resource Identification Initiative To cite this cell line use: ALMC-2 (RRID:CVCL_M526)
Comments Characteristics: Produces IgG lambda.
Omics: Array-based CGH.
Omics: Transcriptome analysis by RNAseq.
Donor information: Established from a patient suffering from primary systemic amyloidosis which relapsed with multiple myeloma.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Cell type: B-cell; CL=CL_0000236.
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_M525 ! ALMC-1
Sex of cell Female
Age at sampling 50Y
Category Cancer cell line
Web pages https://www.keatslab.org/myeloma-cell-lines/hmcl-characteristics
Publications

DOI=10.1182/blood.V112.11.2732.2732
Keats J.J., Arendt B.K., Braggio E., Barrett M.T., Price-Troska T.L., Fonseca R., Bergsagel P.L., Jelinek D.F.
Comparison of multiple myeloma donor patient samples and derived cell lines identifies a confirmed hyperdiploid myeloma cell line and demonstrates remarkable genetic similarity between cell lines and patient samples.
Blood 112 Suppl. 1:2732a-2732a(2008)

PubMed=18567838; DOI=10.1182/blood-2008-03-143040; PMCID=PMC2518895
Arendt B.K., Ramirez-Alvarado M., Sikkink L.A., Keats J.J., Ahmann G.J., Dispenzieri A., Fonseca R., Ketterling R.P., Knudson R.A., Mulvihill E.M., Tschumper R.C., Wu X.-S., Zeldenrust S.R., Jelinek D.F.
Biologic and genetic characterization of the novel amyloidogenic lambda light chain-secreting human cell lines, ALMC-1 and ALMC-2.
Blood 112:1931-1941(2008)

PubMed=23992230; DOI=10.1111/ejh.12192; PMCID=PMC3834223
Greenberg A.J., Walters D.K., Kumar S.K., Rajkumar S.V., Jelinek D.F.
Responsiveness of cytogenetically discrete human myeloma cell lines to lenalidomide: lack of correlation with cereblon and interferon regulatory factor 4 expression levels.
Eur. J. Haematol. 91:504-513(2013)

PubMed=24013424; DOI=10.4161/cc.26193; PMCID=PMC3865013
Walters D.K., Arendt B.K., Jelinek D.F.
CD147 regulates the expression of MCT1 and lactate export in multiple myeloma cells.
Cell Cycle 12:3175-3183(2013)

PubMed=25015330; DOI=10.18632/oncotarget.2159; PMCID=PMC4170605
Arendt B.K., Walters D.K., Wu X., Tschumper R.C., Jelinek D.F.
Multiple myeloma cell-derived microvesicles are enriched in CD147 expression and enhance tumor cell proliferation.
Oncotarget 5:5686-5699(2014)

CLPUB00604
Chow S.
Targeted capture and sequencing of immunoglobulin rearrangements in multiple myeloma to enable detection of minimal residual disease.
Thesis MSc (2017); University of Toronto; Toronto; Canada

PubMed=32123307; DOI=10.1038/s41375-020-0785-1; PMCID=PMC7483300
Sarin V., Yu K., Ferguson I.D., Gugliemini O., Nix M.A., Hann B., Sirota M., Wiita A.P.
Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis.
Leukemia 34:2754-2765(2020)

Cross-references
Encyclopedic resources Wikidata; Q54749244
Entry history
Entry creation05-Nov-2013
Last entry update10-Sep-2024
Version number15