ID   CMA-03
AC   CVCL_M486
SY   CMA03
DR   EFO; EFO_0006552
DR   Cosmic; 2391808
DR   GEO; GSM143344
DR   GEO; GSM290288
DR   GEO; GSM977751
DR   GEO; GSM977752
DR   GEO; GSM977753
DR   GEO; GSM977754
DR   GEO; GSM977755
DR   GEO; GSM977756
DR   Wikidata; Q54813731
RX   PubMed=16266902;
RX   PubMed=17171682;
RX   PubMed=18700954;
RX   PubMed=19306352;
RX   PubMed=24327544;
CC   Characteristics: Produces IgG kappa.
CC   Characteristics: IL6 dependent.
CC   Doubling time: 80 hours (PubMed=16266902).
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Peritoneal effusion; UBERON=UBERON_0001268.
CC   Cell type: B-cell; CL=CL_0000236.
DI   NCIt; C3242; Plasma cell myeloma
DI   ORDO; Orphanet_29073; Multiple myeloma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   53Y
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 10-09-24; Version: 13
//
RX   PubMed=16266902;
RA   Verdelli D., Mattioli M., Fabris S., Nobili L., Intini D.,
RA   Guerneri S., Todoerti K., Zanella A., Lambertenghi-Deliliers G.,
RA   Lombardi L., Neri A.;
RT   "Molecular and biological characterization of three novel
RT   interleukin-6-dependent human myeloma cell lines.";
RL   Haematologica 90:1541-1548(2005).
//
RX   PubMed=17171682; DOI=10.1002/gcc.20404;
RA   Lombardi L., Poretti G., Mattioli M., Fabris S., Agnelli L.,
RA   Bicciato S., Kwee I., Rinaldi A., Ronchetti D., Verdelli D.,
RA   Lambertenghi-Deliliers G., Bertoni F., Neri A.;
RT   "Molecular characterization of human multiple myeloma cell lines by
RT   integrative genomics: insights into the biology of the disease.";
RL   Genes Chromosomes Cancer 46:226-238(2007).
//
RX   PubMed=18700954; DOI=10.1186/1755-8794-1-37; PMCID=PMC2531129;
RA   Ronchetti D., Lionetti M., Mosca L., Agnelli L., Andronache A.,
RA   Fabris S., Lambertenghi-Deliliers G., Neri A.;
RT   "An integrative genomic approach reveals coordinated expression of
RT   intronic miR-335, miR-342, and miR-561 with deregulated host genes in
RT   multiple myeloma.";
RL   BMC Med. Genomics 1:37.1-37.9(2008).
//
RX   PubMed=19306352; DOI=10.1002/gcc.20660;
RA   Lionetti M., Agnelli L., Mosca L., Fabris S., Andronache A.,
RA   Todoerti K., Ronchetti D., Lambertenghi-Deliliers G., Neri A.;
RT   "Integrative high-resolution microarray analysis of human myeloma cell
RT   lines reveals deregulated miRNA expression associated with allelic
RT   imbalances and gene expression profiles.";
RL   Genes Chromosomes Cancer 48:521-531(2009).
//
RX   PubMed=24327544; DOI=10.1002/gcc.22127;
RA   Verdelli D., Nobili L., Todoerti K., Mosca L., Fabris S., D'Anca M.,
RA   Pellegrino E., Piva R., Inghirami G., Capelli C., Introna M.,
RA   Baldini L., Chiaramonte R., Lombardi L., Neri A.;
RT   "Molecular events underlying interleukin-6 independence in a subclone
RT   of the CMA-03 multiple myeloma cell line.";
RL   Genes Chromosomes Cancer 53:154-167(2014).
//