ID   GIST48B
AC   CVCL_M441
SY   GIST-48B
DR   cancercelllines; CVCL_M441
DR   Cosmic; 2805390
DR   GEO; GSM2527249
DR   GEO; GSM2527262
DR   GEO; GSM2527263
DR   GEO; GSM2786736
DR   Wikidata; Q54835859
RX   PubMed=19706776;
RX   PubMed=25239608;
RX   PubMed=29866822;
RX   PubMed=30488756;
CC   Characteristics: Expresses KIT transcript and protein at essentially undetectable levels (PubMed=19706776).
CC   Sequence variation: Mutation; HGNC; HGNC:6342; KIT; Simple; p.Asp820Ala (c.2459A>C); ClinVar=VCV000953798; Zygosity=Heterozygous (PubMed=19706776).
CC   Sequence variation: Mutation; HGNC; HGNC:6342; KIT; Simple; p.Val560Asp (c.1679T>A); ClinVar=VCV000375914; Zygosity=Homozygous (PubMed=19706776).
CC   Omics: Chromatin accessibility by ATAC-seq.
CC   Omics: H3K27ac ChIP-seq epigenome analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Cell type: Interstitial cell of Cajal; CL=CL_0002088.
DI   NCIt; C3868; Gastrointestinal stromal tumor
DI   ORDO; Orphanet_44890; Gastrointestinal stromal tumor
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_7041 ! GIST48
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 19-12-24; Version: 14
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RX   PubMed=19706776; DOI=10.1158/0008-5472.CAN-08-4004; PMCID=PMC2905726;
RA   Muhlenberg T., Zhang Y.-X., Wagner A.J., Grabellus F., Bradner J.E.,
RA   Taeger G., Lang H., Taguchi T., Schuler M., Fletcher J.A., Bauer S.;
RT   "Inhibitors of deacetylases suppress oncogenic KIT signaling,
RT   acetylate HSP90, and induce apoptosis in gastrointestinal stromal
RT   tumors.";
RL   Cancer Res. 69:6941-6950(2009).
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RX   PubMed=25239608; DOI=10.1158/1078-0432.CCR-14-1397; PMCID=PMC4233175;
RA   Garner A.P., Gozgit J.M., Anjum R., Vodala S., Schrock A.B., Zhou T.-J.,
RA   Serrano C., Eilers G., Zhu M.-J., Ketzer J., Wardwell S., Ning Y.,
RA   Song Y., Kohlmann A., Wang F., Clackson T., Heinrich M.C.,
RA   Fletcher J.A., Bauer S., Rivera V.M.;
RT   "Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and
RT   shows therapeutic potential in heavily pretreated gastrointestinal
RT   stromal tumor (GIST) patients.";
RL   Clin. Cancer Res. 20:5745-5755(2014).
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RX   PubMed=29866822; DOI=10.1073/pnas.1802079115; PMCID=PMC6016782;
RA   Hemming M.L., Lawlor M.A., Zeid R., Lesluyes T., Fletcher J.A.,
RA   Raut C.P., Sicinska E.T., Chibon F., Armstrong S.A., Demetri G.D.,
RA   Bradner J.E.;
RT   "Gastrointestinal stromal tumor enhancers support a transcription
RT   factor network predictive of clinical outcome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 115:E5746-E5755(2018).
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RX   PubMed=30488756; DOI=10.1080/15384101.2018.1553335; PMCID=PMC6300111;
RA   Tu Y.-Q., Zuo R., Ni N., Eilers G., Wu D.-L., Pei Y.-T., Nie Z.-M.,
RA   Wu Y.-Q., Wu Y.-H., Ou W.-B.;
RT   "Activated tyrosine kinases in gastrointestinal stromal tumor with
RT   loss of KIT oncoprotein expression.";
RL   Cell Cycle 17:2577-2592(2018).
//