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Cellosaurus MDA-MB-231LLM (CVCL_M354)

[Text version]
Cell line name MDA-MB-231LLM
Accession CVCL_M354
Resource Identification Initiative To cite this cell line use: MDA-MB-231LLM (RRID:CVCL_M354)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=22977471; DOI=10.3892/etm.2010.183; PMCID=PMC3440645
Nukatsuka M., Saito H., Fukushima M.
Establishment of a triple-negative type human breast cancer cell line that selectively metastasizes to the lung after orthotropic implantation.
Exp. Ther. Med. 2:69-72(2011)

Cross-references
Cell line databases/resources cancercelllines; CVCL_M354
Encyclopedic resources Wikidata; Q54904621
Entry history
Entry creation05-Nov-2013
Last entry update05-Oct-2023
Version number20