ID   KKU-213B
AC   CVCL_M264
SY   KKU-M214; KKUM214; M214; KKU-214; KKU214; Khon Kaen University-M214
DR   JCRB; JCRB1556
DR   Wikidata; Q54900011
RX   PubMed=15884115;
RX   PubMed=16475706;
RX   PubMed=18714155;
RX   PubMed=21871105;
RX   PubMed=22926522;
RX   PubMed=25998688;
RX   PubMed=31077409;
RX   PubMed=32207095;
RX   PubMed=35640676;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a KKU-213A derivative (PubMed=32207095 and JCRB web site).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00592.
CC   Population: Southeast Asian; Thai.
CC   Doubling time: 22.68 +- 2.20 hours (PubMed=25998688); 24.5 +- 0.2 hours (PubMed=32207095).
CC   Karyotypic information: Has lost chromosome Y.
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Cys (c.37G>T); ClinVar=VCV000045123; Zygosity=Unspecified (from parent cell line).
CC   Omics: Transcriptomics; Microarray.
CC   Caution: After JCRB found out that KKU-M156 and KKU-M214 were derived from KKU-M213, these three cell lines were renamed by the lab which established them: KKU-M213 became KKU-213A, KKU-M214 became KKU-M213B and KKU-M156 became KKU-M213C (PubMed=32207095).
CC   Discontinued: JCRB; JCRB1556; probable.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
ST   Source(s): PubMed=32207095
ST   Amelogenin: X
ST   CSF1PO: 9,13
ST   D13S317: 8,12
ST   D16S539: 9,11
ST   D18S51: 14
ST   D19S433: 13,14
ST   D21S11: 29
ST   D2S1338: 22,23,24
ST   D3S1358: 15
ST   D5S818: 9
ST   D7S820: 11
ST   D8S1179: 11,13
ST   FGA: 16,19
ST   TH01: 7
ST   TPOX: 8
ST   vWA: 18
DI   NCIt; C35417; Intrahepatic cholangiocarcinoma
DI   NCIt; C27769; Opisthorchis viverrini-related cholangiocarcinoma
DI   ORDO; Orphanet_70567; Cholangiocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_M261 ! KKU-213A
SX   Male
AG   58Y
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 10-04-25; Version: 20
//
RX   PubMed=15884115; DOI=10.3748/wjg.v11.i18.2748; PMCID=PMC4305909;
RA   Tepsiri, Nisana
RA   Chaturat, Liengchai
RA   Sripa, Banchob
RA   Namwat, Wises
RA   Wongkham, Sopit
RA   Bhudhisawasdi, Vajarabhongsa
RA   Tassaneeyakul, Wichittra
RT   "Drug sensitivity and drug resistance profiles of human intrahepatic
RT   cholangiocarcinoma cell lines.";
RL   World J. Gastroenterol. 11:2748-2753(2005).
//
RX   PubMed=16475706;
RA   Panichakul, Tasanee
RA   Intachote, Pakamas
RA   Wongkajornsilp, Adisak
RA   Sripa, Banchob
RA   Sirisinha, Stitaya
RT   "Triptolide sensitizes resistant cholangiocarcinoma cells to
RT   TRAIL-induced apoptosis.";
RL   Anticancer Res. 26:259-265(2006).
//
RX   PubMed=18714155; DOI=10.1159/000151541;
RA   Namwat, Nisana
RA   Amimanan, Piyawan
RA   Loilome, Watcharin
RA   Jearanaikoon, Patcharee
RA   Sripa, Banchob
RA   Bhudhisawasdi, Vajarabhongsa
RA   Tassaneeyakul, Wichittra
RT   "Characterization of 5-fluorouracil-resistant cholangiocarcinoma cell
RT   lines.";
RL   Chemotherapy 54:343-351(2008).
//
RX   PubMed=21871105; DOI=10.1186/1476-4598-10-102; PMCID=PMC3173387;
RA   Obchoei, Sumalee
RA   Weakley, Sarah M.
RA   Wongkham, Sopit
RA   Wongkham, Chaisiri
RA   Sawanyawisuth, Kanlayanee
RA   Yao, Qi-Zhi
RA   Chen, Chang-Yi
RT   "Cyclophilin A enhances cell proliferation and tumor growth of liver
RT   fluke-associated cholangiocarcinoma.";
RL   Mol. Cancer 10:102.1-102.15(2011).
//
RX   PubMed=22926522; DOI=10.1038/onc.2012.382; PMCID=PMC3869796;
RA   Kunkeaw, Nawapol
RA   Jeon, Sung Ho
RA   Lee, Kwanbok
RA   Johnson, Betty H.
RA   Tanasanvimon, Suebpong
RA   Javle, Milind
RA   Pairojkul, Chawalit
RA   Chamgramol, Yaovalux
RA   Wongfieng, Wipaporn
RA   Gong, Bin
RA   Leelayuwat, Chanwit
RA   Lee, Yung Sun
RT   "Cell death/proliferation roles for nc886, a non-coding RNA, in the
RT   protein kinase R pathway in cholangiocarcinoma.";
RL   Oncogene 32:3722-3731(2013).
//
RX   PubMed=25998688; DOI=10.3892/ijo.2015.3019;
RA   Wattanawongdon, Wareeporn
RA   Hahnvajanawong, Chariya
RA   Namwat, Nisana
RA   Kanchanawat, Sirimas
RA   Boonmars, Thidarut
RA   Jearanaikoon, Patcharee
RA   Leelayuwat, Chanwit
RA   Techasen, Anchalee
RA   Seubwai, Wunchana
RT   "Establishment and characterization of gemcitabine-resistant human
RT   cholangiocarcinoma cell lines with multidrug resistance and enhanced
RT   invasiveness.";
RL   Int. J. Oncol. 47:398-410(2015).
//
RX   PubMed=31077409; DOI=10.1002/hep.30704;
RA   Sittithumcharee, Gunya
RA   Suppramote, Orawan
RA   Vaeteewoottacharn, Kulthida
RA   Sirisuksakun, Chumphon
RA   Jamnongsong, Supawan
RA   Laphanuwat, Phatthamon
RA   Suntiparpluacha, Monthira
RA   Matha, Arriya
RA   Chusorn, Porncheera
RA   Buraphat, Pongsakorn
RA   Kakanaporn, Chumpot
RA   Charngkaew, Komgrid
RA   Silsirivanit, Atit
RA   Korphaisarn, Krittiya
RA   Limsrichamrern, Somchai
RA   Tripatara, Pinpat
RA   Pairojkul, Chawalit
RA   Wongkham, Sopit
RA   Sampattavanich, Somponnat
RA   Okada, Seiji
RA   Jirawatnotai, Siwanon
RT   "Dependency of cholangiocarcinoma on cyclin D-dependent kinase
RT   activity.";
RL   Hepatology 70:1614-1630(2019).
//
RX   PubMed=32207095; DOI=10.1007/s13577-020-00334-w;
RA   Sripa, Banchob
RA   Seubwai, Wunchana
RA   Vaeteewoottacharn, Kulthida
RA   Sawanyawisuth, Kanlayanee
RA   Silsirivanit, Atit
RA   Kaewkong, Worasak
RA   Muisuk, Kanha
RA   Dana, Paweena
RA   Phoomak, Chatchai
RA   Lert-itthiporn, Worachart
RA   Luvira, Vor
RA   Pairojkul, Chawalit
RA   Teh, Bin Tean
RA   Wongkham, Sopit
RA   Okada, Seiji
RA   Chamgramol, Yaovalux
RT   "Functional and genetic characterization of three cell lines derived
RT   from a single tumor of an Opisthorchis viverrini-associated
RT   cholangiocarcinoma patient.";
RL   Hum. Cell 33:695-708(2020).
//
RX   PubMed=35640676; DOI=10.1016/j.ajpath.2022.05.007; PMCID=PMC9472155;
RA   Isidan, Abdulkadir
RA   Yenigun, Ali
RA   Soma, Daiki
RA   Aksu, Eric
RA   Lopez, Kevin
RA   Park, Yujin
RA   Cross-Najafi, Arthur
RA   Li, Ping
RA   Kundu, Debjyoti
RA   House, Michael G.
RA   Chakraborty, Sanjukta
RA   Glaser, Shannon
RA   Kennedy, Lindsey
RA   Francis, Heather
RA   Zhang, Wen-Jun
RA   Alpini, Gianfranco D.
RA   Ekser, Burcin
RT   "Development and characterization of human primary cholangiocarcinoma
RT   cell lines.";
RL   Am. J. Pathol. 192:1200-1217(2022).
//