ID   POLZ KO
AC   CVCL_M248
SY   Nalm-6-MSH+/REV3L-/-
DR   cancercelllines; CVCL_M248
DR   JCRB; JCRB1488
DR   Wikidata; Q54947737
CC   Population: Caucasian.
CC   Knockout cell: Method=Homologous recombination; HGNC; 9968; REV3L.
CC   Sequence variation: Gene fusion; HGNC; 50800; DUX4 + HGNC; 5477; IGH; Name(s)=IGH-DUX4; Note=The translocation occurs in the silenced IGH allele (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Arg1068Ter (c.3202C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Ala146Thr (c.436G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9864; RARA; Simple; p.Gln45Ter (c.133C>T); ClinVar=VCV000393019; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; 7325; MSH2 (Note=Exons 9 to 16).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): JCRB=JCRB1488
ST   Amelogenin: X,Y
ST   CSF1PO: 14
ST   D13S317: 9,13
ST   D16S539: 9,11
ST   D5S818: 11,13
ST   D7S820: 8,12
ST   TH01: 8,9
ST   TPOX: 8,10
ST   vWA: 15,16
DI   NCIt; C9143; Adult B acute lymphoblastic leukemia
DI   ORDO; Orphanet_99860; Precursor B-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_J365 ! Nalm-6-MSH+
SX   Male
AG   19Y
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 10-09-24; Version: 18
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