ID   REN
AC   CVCL_M202
SY   Ren
DR   EFO; EFO_0022351
DR   Cosmic; 1963334
DR   Wikidata; Q54949728
RX   PubMed=8010779;
RX   PubMed=8174104;
RX   PubMed=12063468;
RX   PubMed=12707267;
RX   PubMed=18223230;
RX   PubMed=22552293;
CC   Characteristics: Established from a SCID nude mouse xenograft (PubMed=8010779).
CC   Miscellaneous: STR profile from personal communication of Pentimalli, Francesca.
CC   Miscellaneous: Sex and age of donor and site of origin from personal communication of Smythe, William Roy through Pentimalli, Francesca.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C45662; Pleural epithelioid mesothelioma
DI   ORDO; Orphanet_50251; Pleural mesothelioma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   73Y
CA   Cancer cell line
DT   Created: 06-05-13; Last updated: 10-09-24; Version: 12
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RX   PubMed=8010779; DOI=10.1016/0003-4975(94)90090-6;
RA   Smythe W.R., Kaiser L.R., Hwang H.C., Amin K.M., Pilewski J.M.,
RA   Eck S.L., Wilson J.M., Albelda S.M.;
RT   "Successful adenovirus-mediated gene transfer in an in vivo model of
RT   human malignant mesothelioma.";
RL   Ann. Thorac. Surg. 57:1395-1401(1994).
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RX   PubMed=8174104;
RA   Smythe W.R., Hwang H.C., Amin K.M., Eck S.L., Davidson B.L.,
RA   Wilson J.M., Kaiser L.R., Albelda S.M.;
RT   "Use of recombinant adenovirus to transfer the herpes simplex virus
RT   thymidine kinase (HSVtk) gene to thoracic neoplasms: an effective in
RT   vitro drug sensitization system.";
RL   Cancer Res. 54:2055-2059(1994).
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RX   PubMed=12063468; DOI=10.1067/mtc.2002.121684;
RA   Smythe W.R., Mohuiddin I., Ozveran M., Cao X.-B.;
RT   "Antisense therapy for malignant mesothelioma with oligonucleotides
RT   targeting the bcl-xl gene product.";
RL   J. Thorac. Cardiovasc. Surg. 123:1191-1198(2002).
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RX   PubMed=12707267; DOI=10.1074/jbc.M302161200;
RA   Vivo C., Liu W.-H., Broaddus V.C.;
RT   "c-Jun N-terminal kinase contributes to apoptotic synergy induced by
RT   tumor necrosis factor-related apoptosis-inducing ligand plus DNA
RT   damage in chemoresistant, p53 inactive mesothelioma cells.";
RL   J. Biol. Chem. 278:25461-25467(2003).
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RX   PubMed=18223230; DOI=10.1158/1078-0432.CCR-07-1388;
RA   Bertino P., Piccardi F., Porta C., Favoni R.E., Cilli M., Mutti L.,
RA   Gaudino G.;
RT   "Imatinib mesylate enhances therapeutic effects of gemcitabine in
RT   human malignant mesothelioma xenografts.";
RL   Clin. Cancer Res. 14:541-548(2008).
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RX   PubMed=22552293; DOI=10.1158/0008-5472.CAN-11-3481; PMCID=PMC3389268;
RA   Jube S., Rivera Z.S., Bianchi M.E., Powers A., Wang E., Pagano I.,
RA   Pass H.I., Gaudino G., Carbone M., Yang H.-N.;
RT   "Cancer cell secretion of the DAMP protein HMGB1 supports progression
RT   in malignant mesothelioma.";
RL   Cancer Res. 72:3290-3301(2012).
//