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Cellosaurus HKCI-4 (CVCL_M175)

[Text version]
Cell line name HKCI-4
Accession CVCL_M175
Resource Identification Initiative To cite this cell line use: HKCI-4 (RRID:CVCL_M175)
Comments Population: Chinese.
Virology: Expresses chimeric hepatitis B virus (HBV)-human transcripts (PubMed=24582836).
Karyotypic information: Has lost chromosome Y.
Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Adult
Category Cancer cell line
Publications

PubMed=11793441; DOI=10.1002/gcc.1220
Pang E., Wong N., Lai P.B.-S., To K.-F., Lau J.W.-Y., Johnson P.J.
Consistent chromosome 10 rearrangements in four newly established human hepatocellular carcinoma cell lines.
Genes Chromosomes Cancer 33:150-159(2002)

DOI=10.1385/CP:1:3-4:313
Pang R.T.-K., Poon T.C.-W., Wong N., Lai P.B.-S., Wong N.L.-Y., Chan C.M.-L., Yu J.W.S., Chan A.T.-C., Sung J.J.-Y.
Comparison of protein expression patterns between hepatocellular carcinoma cell lines and a hepatoblastoma cell line.
Clin. Proteomics 1:313-331(2004)

PubMed=15645427; DOI=10.1002/ijc.20684
Chan K.Y.-Y., Wong N., Lai P.B.-S., Squire J.A., Macgregor P.F., Beheshti B., Albert M., To K.-F., Johnson P.J.
Transcriptional profiling on chromosome 19p indicated frequent downregulation of ACP5 expression in hepatocellular carcinoma.
Int. J. Cancer 114:902-908(2005)

PubMed=15709204; DOI=10.1158/1078-0432.1319.11.3
Wong N., Chan K.Y.-Y., Macgregor P.F., Lai P.B.-S., Squire J.A., Beheshti B., Albert M., Leung T.W.-T.
Transcriptional profiling identifies gene expression changes associated with IFN-alpha tolerance in hepatitis C-related hepatocellular carcinoma cells.
Clin. Cancer Res. 11:1319-1326(2005)

PubMed=15765123; DOI=10.1038/labinvest.3700254
Pang E., Hu Y., Chan K.Y.-Y., Lai P.B.-S., Squire J.A., Macgregor P.F., Beheshti B., Albert M., Leung T.W.-T., Wong N.
Karyotypic imbalances and differential gene expressions in the acquired doxorubicin resistance of hepatocellular carcinoma cells.
Lab. Invest. 85:664-674(2005)

PubMed=19003983; DOI=10.1002/ijc.23968
Wong N., Yeo W., Wong W.-L., Wong N.L.-Y., Chan K.Y.-Y., Mo F.K.-F., Koh J., Chan S.L., Chan A.T.-C., Lai P.B.-S., Ching A.K.-K., Tong J.H.-M., Ng H.-K., Johnson P.J., To K.-F.
TOP2A overexpression in hepatocellular carcinoma correlates with early age onset, shorter patients survival and chemoresistance.
Int. J. Cancer 124:644-652(2009)

PubMed=23376363; DOI=10.1016/j.jhep.2013.01.032
Law P.T.-Y., Qin H., Ching A.K.-K., Lai K.P., Co N.N., He M., Lung R.W.-M., Chan A.W.-H., Chan T.-F., Wong N.
Deep sequencing of small RNA transcriptome reveals novel non-coding RNAs in hepatocellular carcinoma.
J. Hepatol. 58:1165-1173(2013)

PubMed=24582836; DOI=10.1016/j.ccr.2014.01.030
Lau C.-C., Sun T.-T., Ching A.K.-K., He M., Li J.-W., Wong A.M., Co N.N., Chan A.W.-H., Li P.-S., Lung R.W.-M., Tong J.H.-M., Lai P.B.-S., Chan H.L.-Y., To K.-F., Chan T.-F., Wong N.
Viral-human chimeric transcript predisposes risk to liver cancer development and progression.
Cancer Cell 25:335-349(2014)

Cross-references
Encyclopedic resources Wikidata; Q54889754
Sequence databases EGA; EGAD00001004475
Entry history
Entry creation06-May-2013
Last entry update29-Jun-2023
Version number13