ID   COG-LL-319h
AC   CVCL_M161
DR   GEO; GSM5137711
DR   GEO; GSM5137753
DR   PRIDE; PXD023662
DR   Wikidata; Q54813971
RX   PubMed=22137317;
RX   PubMed=26080839;
RX   PubMed=35354797;
WW   https://www.cccells.org/cellreqs-leuk.php
WW   https://www.cccells.org/PDF_Files/LL-PDX/COG-LL-319.pdf
CC   Characteristics: Hypoxic cell line grown at 5% O2.
CC   Doubling time: 50-62 hours (COG).
CC   Sequence variation: Gene fusion; HGNC; HGNC:8632; PBX1 + HGNC; HGNC:11633; TCF3; Name(s)=TCF3-PBX1, E2A-PBX1 (PubMed=35354797).
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): COG
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 8,12
ST   D16S539: 9,14
ST   D18S51: 12,14
ST   D19S433: 13,14
ST   D21S11: 29,30
ST   D2S1338: 19,25
ST   D3S1358: 15,16
ST   D5S818: 11,13
ST   D7S820: 10,12
ST   D8S1179: 11,15
ST   FGA: 22,23
ST   TH01: 6,9.3
ST   TPOX: 8,10
ST   vWA: 18
DI   NCIt; C9140; Childhood B acute lymphoblastic leukemia
DI   ORDO; Orphanet_99860; Precursor B-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_B3TH ! COG-LL-319
SX   Female
AG   13Y
CA   Cancer cell line
DT   Created: 06-05-13; Last updated: 19-12-24; Version: 14
//
RX   PubMed=22137317; DOI=10.1016/j.leukres.2011.10.022; PMCID=PMC3264762;
RA   Zhang C., Ryu Y.-K., Chen T.Z., Hall C.P., Webster D.R., Kang M.H.;
RT   "Synergistic activity of rapamycin and dexamethasone in vitro and in
RT   vivo in acute lymphoblastic leukemia via cell-cycle arrest and
RT   apoptosis.";
RL   Leuk. Res. 36:342-349(2012).
//
RX   PubMed=26080839; DOI=10.1158/1078-0432.CCR-15-0114; PMCID=PMC4681691;
RA   Hall C.P., Reynolds C.P., Kang M.H.;
RT   "Modulation of glucocorticoid resistance in pediatric T-cell acute
RT   lymphoblastic leukemia by increasing BIM expression with the PI3K/mTOR
RT   inhibitor BEZ235.";
RL   Clin. Cancer Res. 22:621-632(2016).
//
RX   PubMed=35354797; DOI=10.1038/s41467-022-29224-5; PMCID=PMC8967900;
RA   Leo I.R., Aswad L., Stahl M., Kunold E., Post F., Erkers T.,
RA   Struyf N., Mermelekas G., Joshi R.N., Gracia-Villacampa E.,
RA   Ostling P., Kallioniemi O.-P., Pokrovskaja Tamm K., Siavelis I.,
RA   Lehtio J., Vesterlund M., Jafari R.;
RT   "Integrative multi-omics and drug response profiling of childhood
RT   acute lymphoblastic leukemia cell lines.";
RL   Nat. Commun. 13:1691.1-1691.19(2022).
//