Cell line name |
LNCaP C-81 |
Synonyms |
LNCaP-C81 C-81; C81 |
Accession |
CVCL_M131 |
Resource Identification Initiative |
To cite this cell line use: LNCaP C-81 (RRID:CVCL_M131) |
Comments |
Population: Caucasian. Omics: Transcriptome analysis by microarray. Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056. |
Sequence variations |
- Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
- Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
|
Disease |
Prostate carcinoma (NCIt: C4863) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_M129 (LNCaP C-33) |
Sex of cell |
Male |
Age at sampling |
50Y |
Category |
Cancer cell line |
Publications | PubMed=11705865 Karan D., Schmied B.M., Dave B.J., Wittel U.A., Lin M.-F., Batra S.K. Decreased androgen-responsive growth of human prostate cancer is associated with increased genetic alterations. Clin. Cancer Res. 7:3472-3480(2001) PubMed=11870800; DOI=10.1002/pros.10054 Igawa T., Lin F.-F., Lee M.-S., Karan D., Batra S.K., Lin M.-F. Establishment and characterization of androgen-independent human prostate cancer LNCaP cell model. Prostate 50:222-235(2002) PubMed=17977648; DOI=10.1016/j.canlet.2007.09.018; PMCID=PMC2784916 Singh A.P., Bafna S., Chaudhary K., Venkatraman G., Smith L., Eudy J.D., Johansson S.L., Lin M.-F., Batra S.K. Genome-wide expression profiling reveals transcriptomic variation and perturbed gene networks in androgen-dependent and androgen-independent prostate cancer cells. Cancer Lett. 259:28-38(2008) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_M131
|
Encyclopedic resources |
Wikidata; Q54902824
|
Entry history |
Entry creation | 06-May-2013 |
Last entry update | 19-Dec-2024 |
Version number | 18 |
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