| Cell line name |
LNCaP 104-R2 |
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| Synonyms |
LNCaP-104-R2; 104-R2; R2 |
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| Accession |
CVCL_M128 |
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| Resource Identification Initiative |
To cite this cell line use: LNCaP 104-R2 (RRID:CVCL_M128) |
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| Comments |
Population: Caucasian.
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056. |
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| Sequence variations |
- Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
- Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
|
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| Disease |
Prostate carcinoma (NCIt: C4863) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_M127 (LNCaP 104-R1) |
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| Sex of cell |
Male |
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| Age at sampling |
50Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=9658399; DOI=10.1210/mend.12.7.0136
Kokontis J.M., Hay N., Liao S.-T.
Progression of LNCaP prostate tumor cells during androgen deprivation: hormone-independent growth, repression of proliferation by androgen, and role for p27Kip1 in androgen-induced cell cycle arrest.
Mol. Endocrinol. 12:941-953(1998) PubMed=16015608; DOI=10.1002/pros.20285
Kokontis J.M., Hsu S., Chuu C.-P., Dang M., Fukuchi J., Hiipakka R.A., Liao S.-T.
Role of androgen receptor in the progression of human prostate tumor cells to androgen independence and insensitivity.
Prostate 65:287-298(2005) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_M128
|
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| Encyclopedic resources |
Wikidata; Q54902810
|
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| Entry history |
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| Entry creation | 06-May-2013 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 18 |
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