Cellosaurus logo
expasy logo

Cellosaurus LNCaP 104-R2 (CVCL_M128)

[Text version]
Cell line name LNCaP 104-R2
Synonyms LNCaP-104-R2; 104-R2; R2
Accession CVCL_M128
Resource Identification Initiative To cite this cell line use: LNCaP 104-R2 (RRID:CVCL_M128)
Comments Population: Caucasian.
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations
  • Mutation; HGNC; 644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; 7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_M127 (LNCaP 104-R1)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
Publications

PubMed=9658399; DOI=10.1210/mend.12.7.0136
Kokontis J.M., Hay N., Liao S.-T.
Progression of LNCaP prostate tumor cells during androgen deprivation: hormone-independent growth, repression of proliferation by androgen, and role for p27Kip1 in androgen-induced cell cycle arrest.
Mol. Endocrinol. 12:941-953(1998)

PubMed=16015608; DOI=10.1002/pros.20285
Kokontis J.M., Hsu S., Chuu C.-P., Dang M., Fukuchi J., Hiipakka R.A., Liao S.-T.
Role of androgen receptor in the progression of human prostate tumor cells to androgen independence and insensitivity.
Prostate 65:287-298(2005)

Cross-references
Cell line databases/resources cancercelllines; CVCL_M128
Encyclopedic resources Wikidata; Q54902810
Entry history
Entry creation06-May-2013
Last entry update05-Oct-2023
Version number17