ID   GRX
AC   CVCL_M115
DR   BTO; BTO_0003528
DR   BCRJ; 0094
DR   Wikidata; Q54871708
RX   PubMed=2126187;
RX   PubMed=4030623;
RX   PubMed=17760834;
RX   PubMed=35563813;
CC   Characteristics: Established from fibrotic granulomas induced in C3H/HeN mice liver by experimental infection with Schistosoma mansoni (PubMed=2126187).
CC   Derived from site: In situ; Liver; Note=From a granulomatous inflammation; UBERON=UBERON_0002107.
CC   Cell type: Hepatic stellate cell; CL=CL_0000632.
CC   Breed/subspecies: C3H/HeN.
ST   Source(s): PubMed=35563813
ST   Mouse STR 1-1: 10
ST   Mouse STR 1-2: 16
ST   Mouse STR 11-2: 16
ST   Mouse STR 12-1: 16
ST   Mouse STR 13-1: 17
ST   Mouse STR 15-3: 25.3
ST   Mouse STR 17-2: 16
ST   Mouse STR 18-3: 16
ST   Mouse STR 19-2: 12
ST   Mouse STR 2-1: 9
ST   Mouse STR 3-2: 14
ST   Mouse STR 4-2: 19.3
ST   Mouse STR 5-5: 15
ST   Mouse STR 6-4: 19
ST   Mouse STR 6-7: 12
ST   Mouse STR 7-1: 26
ST   Mouse STR 8-1: 16
ST   Mouse STR X-1: 26,27
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_HA25 ! GR [Mouse liver]
SX   Sex unspecified
AG   4M
CA   Spontaneously immortalized cell line
DT   Created: 06-05-13; Last updated: 19-12-24; Version: 14
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RX   PubMed=2126187; PMCID=PMC2002367;
RA   Silva L.-C.F., Borojevic R., Mourao P.A.S.;
RT   "Identification of cells responsible for synthesis of sulphated
RT   glycosaminoglycans in schistosome-induced hepatic granulomas.";
RL   Int. J. Exp. Pathol. 71:845-856(1990).
//
RX   PubMed=4030623; DOI=10.1007/BF02623469;
RA   Borojevic R., Monteiro A.N.A., Vinhas S.A., Domont G.B.,
RA   Mourao P.A.S., Emonard H., Grimaldi G. Jr., Grimaud J.-A.;
RT   "Establishment of a continuous cell line from fibrotic schistosomal
RT   granulomas in mice livers.";
RL   In Vitro Cell. Dev. Biol. 21:382-390(1985).
//
RX   PubMed=17760834; DOI=10.1111/j.1582-4934.2007.00060.x; PMCID=PMC3823251;
RA   Herrmann J., Gressner A.M., Weiskirchen R.;
RT   "Immortal hepatic stellate cell lines: useful tools to study hepatic
RT   stellate cell biology and function?";
RL   J. Cell. Mol. Med. 11:704-722(2007).
//
RX   PubMed=35563813; DOI=10.3390/cells11091504; PMCID=PMC9102025;
RA   Schroder S.K., Schuler H.M., Petersen K.V., Tesauro C., Knudsen B.R.,
RA   Pedersen F.S., Krus F., Buhl E.M., Roeb E., Roderfeld M.,
RA   Borojevic R., Almeida J.L., Weiskirchen R.;
RT   "Genetic and molecular characterization of the immortalized murine
RT   hepatic stellate cell line GRX.";
RL   Cells 11:1504.1-1504.20(2022).
//