ID   PM-1 [Human oral dysplasia]
AC   CVCL_LN13
SY   PM1
DR   CancerTools; 153571
DR   Cosmic; 2688661
DR   GEO; GSM2611476
DR   GEO; GSM2611477
DR   GEO; GSM2611478
DR   Wikidata; Q54947601
DR   Ximbio; 153571
RX   PubMed=10772384;
RX   PubMed=24662767;
RX   PubMed=30202019;
RX   PubMed=31336867;
CC   Sequence variation: Mutation; HGNC; 5173; HRAS; Simple; p.Asn86Ser (c.257A>G); Zygosity=Unspecified (PubMed=24662767).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gly177Glu (c.530G>A); Zygosity=Unspecified (PubMed=24662767).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu258Lys (c.772G>A); ClinVar=VCV000012348; Zygosity=Unspecified (PubMed=24662767).
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Forehead, skin; UBERON=UBERON_0016475.
CC   Cell type: Keratinocyte; CL=CL_0000312.
ST   Source(s): PubMed=31336867
ST   Amelogenin: X,Y
ST   CSF1PO: 9,13
ST   D13S317: 8,12
ST   D16S539: 11,13
ST   D18S51: 18,19
ST   D19S433: 14
ST   D21S11: 30.2,33.2
ST   D2S1338: 17,21
ST   D3S1358: 14
ST   D5S818: 11,12
ST   D7S820: 7,8
ST   D8S1179: 12,15
ST   FGA: 24
ST   TH01: 8,9.3
ST   TPOX: 9,11
ST   vWA: 18,19
DI   NCIt; C129863; Oral epithelial dysplasia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_LN09 ! MET-1
OI   CVCL_LN10 ! MET-2
OI   CVCL_LN11 ! MET-3
OI   CVCL_LN12 ! MET-4
OI   CVCL_VJ50 ! SCCT9
SX   Male
AG   46Y
CA   Transformed cell line
DT   Created: 15-11-17; Last updated: 30-01-24; Version: 11
//
RX   PubMed=10772384; DOI=10.1034/j.1600-0625.2000.009002104.x;
RA   Proby C.M., Purdie K.J., Sexton C.J., Purkis P., Navsaria H.A.,
RA   Stables J.N., Leigh I.M.;
RT   "Spontaneous keratinocyte cell lines representing early and advanced
RT   stages of malignant transformation of the epidermis.";
RL   Exp. Dermatol. 9:104-117(2000).
//
RX   PubMed=24662767; DOI=10.1038/jid.2014.154; PMCID=PMC4753672;
RA   South A.P., Purdie K.J., Watt S.A., Haldenby S., den Breems N.Y.,
RA   Dimon M., Arron S.T., Kluk M.J., Aster J.C., McHugh A., Xue D.J.,
RA   Dayal J.H.S., Robinson K.S., Rizvi S.M.H., Proby C.M., Harwood C.A.,
RA   Leigh I.M.;
RT   "NOTCH1 mutations occur early during cutaneous squamous cell
RT   carcinogenesis.";
RL   J. Invest. Dermatol. 134:2630-2638(2014).
//
RX   PubMed=30202019; DOI=10.1038/s41467-018-06027-1; PMCID=PMC6131170;
RA   Inman G.J., Wang J., Nagano A., Alexandrov L.B., Purdie K.J.,
RA   Taylor R.G., Sherwood V., Thomson J., Hogan S., Spender L.C.,
RA   South A.P., Stratton M.R., Chelala C., Harwood C.A., Proby C.M.,
RA   Leigh I.M.;
RT   "The genomic landscape of cutaneous SCC reveals drivers and a novel
RT   azathioprine associated mutational signature.";
RL   Nat. Commun. 9:3667.1-3667.14(2018).
//
RX   PubMed=31336867; DOI=10.3390/ijms20143428; PMCID=PMC6678499;
RA   Hassan S., Purdie K.J., Wang J., Harwood C.A., Proby C.M.,
RA   Pourreyron C., Mladkova N., Nagano A., Dhayade S., Athineos D.,
RA   Caley M., Mannella V., Blyth K., Inman G.J., Leigh I.M.;
RT   "A Unique panel of patient-derived cutaneous squamous cell carcinoma
RT   cell lines provides a preclinical pathway for therapeutic testing.";
RL   Int. J. Mol. Sci. 20:3428.1-3428.26(2019).
//