ID   MET-4
AC   CVCL_LN12
SY   MET4; SCCTMet
DR   CancerTools; 153570
DR   GEO; GSM2611473
DR   GEO; GSM2611474
DR   GEO; GSM2611475
DR   Wikidata; Q54905320
DR   Ximbio; 153570
RX   PubMed=10772384;
RX   PubMed=11121147;
RX   PubMed=29755650;
RX   PubMed=30202019;
RX   PubMed=31336867;
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: Metastatic; Left axillary lymph node; UBERON=UBERON_0001097.
ST   Source(s): PubMed=31336867
ST   Amelogenin: X,Y
ST   CSF1PO: 13
ST   D13S317: 8,12
ST   D16S539: 11,13
ST   D18S51: 18,19
ST   D19S433: 14
ST   D21S11: 30.2,33.2
ST   D2S1338: 17,21
ST   D3S1358: 16
ST   D5S818: 11,12
ST   D7S820: 7,8
ST   D8S1179: 12,15
ST   FGA: 24
ST   TH01: 9.3
ST   TPOX: 9,11
ST   vWA: 18,19
DI   NCIt; C4819; Skin squamous cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_LN09 ! MET-1
OI   CVCL_LN10 ! MET-2
OI   CVCL_LN11 ! MET-3
OI   CVCL_LN13 ! PM-1 [Human oral dysplasia]
OI   CVCL_VJ50 ! SCCT9
SX   Male
AG   46Y
CA   Cancer cell line
DT   Created: 15-11-17; Last updated: 10-04-25; Version: 9
//
RX   PubMed=11121147; DOI=10.1046/j.1523-1747.2000.00173.x;
RA   Popp, Susanne
RA   Waltering, Stefan
RA   Holtgreve-Grez, Heidi
RA   Jauch, Anna
RA   Proby, Charlotte Mary
RA   Leigh, Irene May
RA   Boukamp, Petra
RT   "Genetic characterization of a human skin carcinoma progression model:
RT   from primary tumor to metastasis.";
RL   J. Invest. Dermatol. 115:1095-1103(2000).
//
RX   PubMed=29755650; DOI=10.18632/oncotarget.24750; PMCID=PMC5945540;
RA   McHugh, Angela
RA   Fernandes, Kenneth
RA   South, Andrew P.
RA   Mellerio, Jemima Elizabet
RA   Salas-Alanis, Julio Cesar
RA   Proby, Charlotte Mary
RA   Leigh, Irene May
RA   Saville, Mark K.
RT   "Preclinical comparison of proteasome and ubiquitin E1 enzyme
RT   inhibitors in cutaneous squamous cell carcinoma: the identification of
RT   mechanisms of differential sensitivity.";
RL   Oncotarget 9:20265-20281(2018).
//
RX   PubMed=30202019; DOI=10.1038/s41467-018-06027-1; PMCID=PMC6131170;
RA   Inman, Gareth J.
RA   Wang, Jun
RA   Nagano, Ai
RA   Alexandrov, Ludmil B.
RA   Purdie, Karin J.
RA   Taylor, Richard G.
RA   Sherwood, Victoria
RA   Thomson, Jason
RA   Hogan, Sarah
RA   Spender, Lindsay C.
RA   South, Andrew P.
RA   Stratton, Michael Rudolf
RA   Chelala, Claude
RA   Harwood, Catherine A.
RA   Proby, Charlotte Mary
RA   Leigh, Irene May
RT   "The genomic landscape of cutaneous SCC reveals drivers and a novel
RT   azathioprine associated mutational signature.";
RL   Nat. Commun. 9:3667.1-3667.14(2018).
//
RX   PubMed=31336867; DOI=10.3390/ijms20143428; PMCID=PMC6678499;
RA   Hassan, Sakinah
RA   Purdie, Karin J.
RA   Wang, Jun
RA   Harwood, Catherine A.
RA   Proby, Charlotte Mary
RA   Pourreyron, Celine
RA   Mladkova, Nikol
RA   Nagano, Ai
RA   Dhayade, Sandeep
RA   Athineos, Dimitris
RA   Caley, Matthew
RA   Mannella, Viviana
RA   Blyth, Karen
RA   Inman, Gareth J.
RA   Leigh, Irene May
RT   "A Unique panel of patient-derived cutaneous squamous cell carcinoma
RT   cell lines provides a preclinical pathway for therapeutic testing.";
RL   Int. J. Mol. Sci. 20:3428.1-3428.26(2019).
//
RX   PubMed=10772384; DOI=10.1034/j.1600-0625.2000.009002104.x;
RA   Proby, Charlotte Mary
RA   Purdie, Karin J.
RA   Sexton, Connie J.
RA   Purkis, Patricia
RA   Navsaria, Harshad Ambaram
RA   Stables, Jeremy N.
RA   Leigh, Irene May
RT   "Spontaneous keratinocyte cell lines representing early and advanced
RT   stages of malignant transformation of the epidermis.";
RL   Exp. Dermatol. 9:104-117(2000).
//