Cellosaurus cell line MCC-60 (CVCL

Cellosaurus MCC-60 (CVCL_LM85)

[Text version]

Cell line name

MCC-60

Synonyms

P3-CL; CL3

Accession

CVCL_LM85

Secondary accession

CVCL_A1QM

Resource Identification Initiative

To cite this cell line use: MCC-60 (RRID:CVCL_LM85)

Comments

Population: Caucasian.
Doubling time: 42 hours (PubMed=33087752); ~70-80 hours (DSMZ=ACC-815).
Omics: Array-based CGH.
Derived from site: In situ; Colon, ascending; UBERON=UBERON_0001156.

Sequence variations

Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=33087752).
Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465His (c.1394G>A); ClinVar=VCV000376415; Zygosity=Heterozygous (PubMed=33087752).
Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Arg233Ter (c.697C>T); ClinVar=VCV000007813; Zygosity=Heterozygous (PubMed=33087752).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg267Trp (c.799C>T); ClinVar=VCV000141764; Zygosity=Heterozygous (PubMed=33087752).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro301Glnfs*44 (c.902delC); ClinVar=VCV000233908; Zygosity=Heterozygous (PubMed=33087752).

Disease

Colon adenocarcinoma (NCIt: C4349)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

65Y

Category

Cancer cell line

STR profile

Source(s): DSMZ=ACC-815; PubMed=33087752

Markers:

Amelogenin	X,Y
CSF1PO	11,12 (PubMed=33087752) 9,12 (DSMZ=ACC-815)
D2S1338	17,24
D3S1358	13,18,19
D5S818	11,13
D7S820	12 (DSMZ=ACC-815) 9.3,10.3,13 (PubMed=33087752)
D8S1179	11,13
D13S317	10 (DSMZ=ACC-815) 13 (PubMed=33087752)
D16S539	8,14
D18S51	17,19
D19S433	13,14
D21S11	33,34
FGA	19,20,22.2
Penta D	12,14
Penta E	16
TH01	7,8,9 (PubMed=33087752) 7,9 (DSMZ=ACC-815)
TPOX	8 (DSMZ=ACC-815) 8,11 (PubMed=33087752)
vWA	13,18 (PubMed=33087752) 14,18 (DSMZ=ACC-815)

Publications

PubMed=33087752; DOI=10.1038/s41598-020-74797-0; PMCID=PMC7578805
Hirsch D., Seyfried S., Staib T., Fiedler D., Sauer C., Ried T., Witt S., Rueckert F., Gaiser T.
Newly established gastrointestinal cancer cell lines retain the genomic and immunophenotypic landscape of their parental cancers.
Sci. Rep. 10:17895-17895(2020)

Cross-references

Cell line collections (Providers)

DSMZ; ACC-815

Cell line databases/resources

cancercelllines; CVCL_LM85
DSMZCellDive; ACC-815

Encyclopedic resources

Wikidata; Q54904248

Gene expression databases

GEO; GSM4563057

Entry history

Entry creation

15-Nov-2017

Last entry update

19-Dec-2024

Version number