ID   HB1.F3
AC   CVCL_LJ44
SY   F3; F3-WT
DR   BTO; BTO_0002893
DR   GEO; GSM456723
DR   GEO; GSM456725
DR   Wikidata; Q54881352
RX   PubMed=12167771;
RX   PubMed=15484694;
RX   PubMed=19813087;
RX   PubMed=21755312;
RX   PubMed=25096191;
RX   PubMed=25198726;
RX   PubMed=28830458;
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P01110; Avian myelocytomatosis virus MC29 v-Myc.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: v-Myc.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Fetal brain, telencephalon; UBERON=UBERON_0014371.
CC   Cell type: Neural stem cell; CL=CL_0000047.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   14FW
CA   Transformed cell line
DT   Created: 15-11-17; Last updated: 19-12-24; Version: 9
//
RX   PubMed=12167771; DOI=10.1097/00001756-200208070-00020;
RA   Cho T., Bae J.-H., Choi H.B., Kim S.S., McLarnon J.G., Suh-Kim H.,
RA   Kim S.U., Min C.K.;
RT   "Human neural stem cells: electrophysiological properties of
RT   voltage-gated ion channels.";
RL   NeuroReport 13:1447-1452(2002).
//
RX   PubMed=15484694; DOI=10.1111/j.1440-1789.2004.00552.x;
RA   Kim S.U.;
RT   "Human neural stem cells genetically modified for brain repair in
RT   neurological disorders.";
RL   Neuropathology 24:159-171(2004).
//
RX   PubMed=19813087; DOI=10.1007/s10571-009-9466-3;
RA   Satoh J.-i., Obayashi S., Tabunoki H., Wakana T., Kim S.U.;
RT   "Stable expression of neurogenin 1 induces LGR5, a novel stem cell
RT   marker, in an immortalized human neural stem cell line HB1.F3.";
RL   Cell. Mol. Neurobiol. 30:415-426(2010).
//
RX   PubMed=21755312; DOI=10.1007/s12015-011-9280-4; PMCID=PMC4043123;
RA   Lee J.-S., Lee H.J., Moon B.-H., Song S.-H., Lee M.-O., Shim S.H.,
RA   Kim H.S., Lee M.C., Kwon J.T., Fornace A.J. Jr., Kim S.U.,
RA   Cha H.-J.;
RT   "Generation of cancerous neural stem cells forming glial tumor by
RT   oncogenic stimulation.";
RL   Stem Cell Rev. Rep. 8:532-545(2012).
//
RX   PubMed=25096191; DOI=10.1093/neuonc/nou145; PMCID=PMC4483050;
RA   Lee J.-S., Park J.-R., Kwon O.-S., Lee T.-H., Nakano I., Miyoshi H.,
RA   Chun K.-H., Park M.-J., Lee H.J., Kim S.U., Cha H.-J.;
RT   "SIRT1 is required for oncogenic transformation of neural stem cells
RT   and for the survival of 'cancer cells with neural stemness' in a
RT   p53-dependent manner.";
RL   Neuro-oncol. 17:95-106(2015).
//
RX   PubMed=25198726; DOI=10.1371/journal.pone.0105129; PMCID=PMC4157740;
RA   Hwang D.W., Jin Y., Lee D.H., Kim H.Y., Cho H.N., Chung H.J., Park Y.,
RA   Youn H., Lee S.J., Lee H.J., Kim S.U., Wang K.-C., Lee D.S.;
RT   "In vivo bioluminescence imaging for prolonged survival of
RT   transplanted human neural stem cells using 3D biocompatible scaffold
RT   in corticectomized rat model.";
RL   PLoS ONE 9:E105129-E105129(2014).
//
RX   PubMed=28830458; DOI=10.1186/s12943-017-0703-y; PMCID=PMC5567886;
RA   Kwon S.-J., Kwon O.-S., Kim K.-T., Go Y.-H., Yu S.-I., Lee B.-H.,
RA   Miyoshi H., Oh E., Cho S.-J., Cha H.-J.;
RT   "Role of MEK partner-1 in cancer stemness through MEK/ERK pathway in
RT   cancerous neural stem cells, expressing EGFRviii.";
RL   Mol. Cancer 16:140.1-140.13(2017).
//