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Cellosaurus DX3-LT5.1 (CVCL_LI22)

[Text version]
Cell line name DX3-LT5.1
Synonyms DX3.LT5.1; DX3 LT5.1; DX3LT5.1; DX3-azaC-LT5.1; LT5.1
Accession CVCL_LI22
Resource Identification Initiative To cite this cell line use: DX3-LT5.1 (RRID:CVCL_LI22)
Comments Characteristics: Highly metastatic in mice.
Selected for resistance to: ChEBI; CHEBI_2038; 5-azacytidine (5-azaC).
Omics: Proteomics; 2DE.
Derived from site: Metastatic; Hypodermis; UBERON=UBERON_0002072.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Heterozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5650 (SK-MEL-93 DX-3)
Children:
CVCL_VS22 (DX3-LT5.1 HmR1)
Sex of cell Female
Age at sampling 71Y
Category Cancer cell line
Publications

PubMed=2416434
Ormerod E.J., Everett C.A., Hart I.R.
Enhanced experimental metastatic capacity of a human tumor line following treatment with 5-azacytidine.
Cancer Res. 46:884-890(1986)

PubMed=2060182; DOI=10.1007/BF01753726
Easty D.J., Hart I.R., Patel K., Seymour C., Yacoub M.H., Domscheit A., Gunther S., Postel W., Gorg A., Dunn M.J.
Changes in protein expression during melanoma differentiation determined by computer analysis of 2-D gels.
Clin. Exp. Metastasis 9:221-230(1991)

PubMed=7780963
Easty D.J., Guthrie B.A., Maung K., Farr C.J., Lindberg R.A., Toso R.J., Herlyn M., Bennett D.C.
Protein B61 as a new growth factor: expression of B61 and up-regulation of its receptor epithelial cell kinase during melanoma progression.
Cancer Res. 55:2528-2532(1995)

Cross-references
Encyclopedic resources Wikidata; Q54831608
Entry history
Entry creation15-Nov-2017
Last entry update10-Apr-2025
Version number8