ID   Jurkat 1F2-hGITR
AC   CVCL_LH48
SY   1F2-hGITR
DR   cancercelllines; CVCL_LH48
DR   Wikidata; Q54899128
RX   PubMed=28847736;
CC   Population: Caucasian.
CC   Characteristics: One of the two IL2 alleles was inactived by CRISPR/Cas9 and a luciferase reporter gene was inserted in the loci thus expressing the luciferase gene under the control of endogenous IL2 promoter.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; 6001; IL2 (Note=1 of 2 alleles).
CC   Sequence variation: Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11491; SYK; Simple; p.Met34Hisfs*3 (c.98_99insG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; 11914; TNFRSF18.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Firefly luciferase.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_LH47 ! Jurkat 1F2
SX   Male
AG   14Y
CA   Cancer cell line
DT   Created: 15-11-17; Last updated: 10-09-24; Version: 17
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RX   PubMed=28847736; DOI=10.1016/j.jim.2017.08.006;
RA   Liu J.-Q., Liu R., Gray P., Liu Z.-Y., Cui X.-X., Li G.-H., Liu Z.;
RT   "Development of a luciferase reporter Jurkat cell line under the
RT   control of endogenous interleukin-2 promoter.";
RL   J. Immunol. Methods 451:48-53(2017).
//