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Cellosaurus HCC1954-NR (CVCL_LG21)

[Text version]
Cell line name HCC1954-NR
Accession CVCL_LG21
Resource Identification Initiative To cite this cell line use: HCC1954-NR (RRID:CVCL_LG21)
Comments Population: East Indian.
Selected for resistance to: ChEBI; CHEBI_61397; Neratinib (Nerlynx; HKI-272).
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Sequence variations
  • Gene fusion; HGNC; HGNC:2092; CLTC + HGNC; HGNC:29559; VMP1; Name(s)=CLTC-VMP1 (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr163Cys (c.488A>G); ClinVar=VCV000127814; Zygosity=Homozygous (from parent cell line).
Disease Breast ductal carcinoma (NCIt: C4017)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1259 (HCC1954)
Sex of cell Female
Age at sampling 61Y
Category Cancer cell line
Publications

PubMed=24876102; DOI=10.1158/0008-5472.CAN-13-2053
Rani S., Corcoran C., Shiels L., Germano S., Breslin S., Madden S.F., McDermott M.S., Browne B.C., O'Donovan N., Crown J., Gogarty M., Byrne A.T., O'Driscoll L.
Neuromedin U: a candidate biomarker and therapeutic target to predict and overcome resistance to HER-tyrosine kinase inhibitors.
Cancer Res. 74:3821-3833(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_LG21
Encyclopedic resources Wikidata; Q54881622
Entry history
Entry creation15-Nov-2017
Last entry update19-Dec-2024
Version number13