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Cellosaurus NIH 3T3/HER2-3(400) (CVCL_LG16)

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Cell line name NIH 3T3/HER2-3(400)
Synonyms NIH 3T3/HER2-3 400; NIH 3T3/HER2-3400
Accession CVCL_LG16
Resource Identification Initiative To cite this cell line use: NIH 3T3/HER2-3(400) (RRID:CVCL_LG16)
Comments Characteristics: Transfected with at least 55 copies of ERBB2 under the control of a SV40 promoter.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:3430; ERBB2.
Genetic integration: Method=Transfection/transduction; Gene=MGI; MGI:94890; Dhfr.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Whole embryo; UBERON=UBERON_0000922.
Cell type: Fibroblast; CL=CL_0000057.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: NIH Swiss.
Hierarchy Parent: CVCL_0594 (NIH 3T3)
Sex of cell Male
Age at sampling Embryo
Category Spontaneously immortalized cell line
Publications

PubMed=2890160; DOI=10.1073/pnas.84.20.7159; PMCID=PMC299249
Hudziak R.M., Schlessinger J., Ullrich A.
Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells.
Proc. Natl. Acad. Sci. U.S.A. 84:7159-7163(1987)

PubMed=2566907; DOI=10.1128/mcb.9.3.1165-1172.1989; PMCID=PMC362707
Hudziak R.M., Lewis Phillips G.D., Winget M., Fendly B.M., Shepard H.M., Ullrich A.
p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor.
Mol. Cell. Biol. 9:1165-1172(1989)

PubMed=1689212
Fendly B.M., Winget M., Hudziak R.M., Lipari M.T., Napier M.A., Ullrich A.
Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2/neu gene product.
Cancer Res. 50:1550-1558(1990)

Cross-references
Encyclopedic resources Wikidata; Q54930583
Entry history
Entry creation15-Nov-2017
Last entry update19-Dec-2024
Version number8