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Cellosaurus MCF-10A EGFR (T790M/+) (CVCL_LD17)

[Text version]
Cell line name MCF-10A EGFR (T790M/+)
Synonyms EGFR (T790M/+) MCF10A
Accession CVCL_LD17
Resource Identification Initiative To cite this cell line use: MCF-10A EGFR (T790M/+) (RRID:CVCL_LD17)
Comments Characteristics: Heterozygous knockin of a EGFR mutation conferring drug resistance.
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008359.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 3236; EGFR; Simple_edited; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Heterozygous; Note=By method not specified (Horizon_Discovery=HD+101-019).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0598 (MCF-10A)
Sex of cell Female
Age at sampling 36Y
Category Spontaneously immortalized cell line
Cell line collections (Providers) Horizon_Discovery; HD+101-019
Encyclopedic resources Wikidata; Q54904285
Entry history
Entry creation22-Aug-2017
Last entry update30-Jan-2024
Version number12