| Cell line name |
LIM1215 KRAS (G12A/+) |
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| Synonyms |
KRAS (G12A/+) LIM1215 |
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| Accession |
CVCL_LC77 |
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| Resource Identification Initiative |
To cite this cell line use: LIM1215 KRAS (G12A/+) (RRID:CVCL_LC77) |
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| Comments |
Population: Caucasian.
Characteristics: Heterozygous knockin of a KRAS activating mutation.
Derived from site: Metastatic; Omentum; UBERON=UBERON_0003688. |
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| Sequence variations |
- Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Pro423Gln (c.1268C>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Thr41Ala (c.121A>G); ClinVar=VCV000017580; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple_edited; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Heterozygous; Note=By method not specified (Horizon_Discovery=HD+116-003).
- Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Colon adenocarcinoma (NCIt: C4349)
Lynch syndrome (NCIt: C8494)
Lynch syndrome (ORDO: Orphanet_144) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_2574 (LIM1215) |
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| Sex of cell |
Male |
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| Age at sampling |
34Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=22722830; DOI=10.1038/nature11156; PMCID=PMC3927413
Misale S., Yaeger R.D., Hobor S., Scala E., Janakiraman M., Liska D., Valtorta E., Schiavo R., Buscarino M., Siravegna G., Bencardino K., Cercek A., Chen C.-T., Veronese S., Zanon C., Sartore-Bianchi A., Gambacorta M., Gallicchio M., Vakiani E., Boscaro V., Medico E., Weiser M.R., Siena S., Di Nicolantonio F., Solit D.B., Bardelli A.
Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer.
Nature 486:532-536(2012) |
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| Cross-references |
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| Cell line collections (Providers) |
Horizon_Discovery; HD+116-003
|
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| Cell line databases/resources |
cancercelllines; CVCL_LC77
|
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| Encyclopedic resources |
Wikidata; Q54902518
|
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| Entry history |
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| Entry creation | 22-Aug-2017 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 14 |
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