ID   NISK9
AC   CVCL_LB87
SY   NISK 9
DR   Wikidata; Q54930632
RX   Patent=US6372501;
RX   PubMed=10567373;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, European Collection of Cell Cultures (ECACC); 09709106.
CC   Characteristics: Insulin secreting.
CC   Characteristics: Compared to the parent cell line, it has a repaired ATP-regulated potassium channel activity.
CC   Transfected with: HGNC; 59; ABCC8.
CC   Transfected with: HGNC; 6257; KCNJ11.
CC   Transfected with: HGNC; 6107; PDX1.
DI   NCIt; C122923; Persistent hyperinsulinemic hypoglycemia of infancy
DI   ORDO; Orphanet_276575; Autosomal dominant hyperinsulinism due to SUR1 deficiency
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_LB86 ! NES2Y
CA   Spontaneously immortalized cell line
DT   Created: 22-08-17; Last updated: 21-03-23; Version: 6
//
RX   Patent=US6372501;
RA   Aynsley-Green A., Lindley K.J., Docherty K., Dunne M.J.,
RA   Macfarlane W.M., James R.F.L.;
RT   "Glucose responsive beta-cell line.";
RL   Patent number US6372501, 16-Apr-2002.
//
RX   PubMed=10567373; DOI=10.1074/jbc.274.48.34059;
RA   Macfarlane W.M., Chapman J.C., Shepherd R.M., Hashmi M.N.,
RA   Kamimura N., Cosgrove K.E., O'Brien R.E., Barnes P.D., Hart A.W.,
RA   Docherty H.M., Lindley K.J., Aynsley-Green A., James R.F.L.,
RA   Docherty K., Dunne M.J.;
RT   "Engineering a glucose-responsive human insulin-secreting cell line
RT   from islets of Langerhans isolated from a patient with persistent
RT   hyperinsulinemic hypoglycemia of infancy.";
RL   J. Biol. Chem. 274:34059-34066(1999).
//