ID   EndoC-betaH1
AC   CVCL_L909
SY   EndoC-BH1
DR   GEO; GSE118588
DR   PRIDE; PXD027920
DR   Wikidata; Q54832322
RX   PubMed=21865645;
RX   PubMed=21865653;
RX   PubMed=25803449;
RX   PubMed=25822155;
RX   PubMed=26901817;
RX   PubMed=29307512;
RX   PubMed=30251567;
RX   PubMed=31976379;
WW   https://web.archive.org/web/20170502035118/http://www.endocells.com/products-and-services/
WW   https://www.humancelldesign.com/human-beta-cells-endoc-bh1/
CC   Characteristics: Secretes insulin in response to glucose challenge.
CC   Virology: Contains an integrated xenotropic MuLV-related virus (XMRV) Bxv-1 (PubMed=26901817).
CC   Doubling time: 5 days (PubMed=21865645); 174 hours (PubMed=25803449).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Omics: H3K27ac ChIP-seq epigenome analysis.
CC   Omics: H3K27me3 ChIP-seq epigenome analysis.
CC   Omics: H3K36me3 ChIP-seq epigenome analysis.
CC   Omics: H3K4me1 ChIP-seq epigenome analysis.
CC   Omics: H3K4me3 ChIP-seq epigenome analysis.
CC   Omics: H3K79me2 ChIP-seq epigenome analysis.
CC   Omics: H3K9me2 ChIP-seq epigenome analysis.
CC   Omics: H3K9me3 ChIP-seq epigenome analysis.
CC   Omics: miRNA expression profiling.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Miscellaneous: Sex assignment derived from omics analysis.
CC   Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
CC   Cell type: Pancreatic beta cell; CL=CL_0000169.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   7-11FW
CA   Transformed cell line
DT   Created: 06-05-13; Last updated: 19-12-24; Version: 23
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RX   PubMed=21865645; DOI=10.1172/JCI58447; PMCID=PMC3163974;
RA   Ravassard P., Hazhouz Y., Pechberty S., Bricout-Neveu E., Armanet M.,
RA   Czernichow P., Scharfmann R.;
RT   "A genetically engineered human pancreatic beta cell line exhibiting
RT   glucose-inducible insulin secretion.";
RL   J. Clin. Invest. 121:3589-3597(2011).
//
RX   PubMed=21865653; DOI=10.1172/JCI58899; PMCID=PMC3163975;
RA   Weir G.C., Bonner-Weir S.;
RT   "Finally! A human pancreatic beta cell line.";
RL   J. Clin. Invest. 121:3395-3397(2011).
//
RX   PubMed=25803449; DOI=10.1371/journal.pone.0120879; PMCID=PMC4372368;
RA   Andersson L.E., Valtat B., Bagge A., Sharoyko V.V., Nicholls D.G.,
RA   Ravassard P., Scharfmann R., Spegel P., Mulder H.;
RT   "Characterization of stimulus-secretion coupling in the human
RT   pancreatic EndoC-betaH1 beta cell line.";
RL   PLoS ONE 10:E0120879-E0120879(2015).
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RX   PubMed=25822155; DOI=10.1097/MPA.0000000000000318;
RA   Krishnan K., Ma Z.-H., Bjorklund A., Islam M.S.;
RT   "Calcium signaling in a genetically engineered human pancreatic
RT   beta-cell line.";
RL   Pancreas 44:773-777(2015).
//
RX   PubMed=26901817; DOI=10.1172/JCI83573; PMCID=PMC4767346;
RA   Kirkegaard J.S., Ravassard P., Ingvarsen S.Z., Diedisheim M.,
RA   Bricout-Neveu E., Gronborg M., Frogne T., Scharfmann R., Madsen O.D.,
RA   Rescan C., Albagli-Curiel O.;
RT   "Xenotropic retrovirus Bxv1 in human pancreatic beta cell lines.";
RL   J. Clin. Invest. 126:1109-1113(2016).
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RX   PubMed=29307512; DOI=10.1016/j.molmet.2017.12.007; PMCID=PMC5985049;
RA   Tsonkova V.G., Sand F.W., Wolf X.A., Grunnet L.G.,
RA   Ringgaard A.K., Ingvorsen C., Winkel L., Kalisz M.,
RA   Dalgaard K., Bruun C., Fels J.J., Helgstrand C., Hastrup S.,
RA   Oberg F.K., Vernet E., Sandrini M.P.B., Shaw A.C., Jessen C.,
RA   Gronborg M., Hald J., Willenbrock H., Madsen D., Wernersson R.,
RA   Hansson L., Jensen J.N., Plesner A., Alanentalo T., Petersen M.B.K.,
RA   Grapin-Botton A., Honore C., Ahnfelt-Ronne J., Hecksher-Sorensen J.,
RA   Ravassard P., Madsen O.D., Rescan C., Frogne T.;
RT   "The EndoC-betaH1 cell line is a valid model of human beta cells and
RT   applicable for screenings to identify novel drug target candidates.";
RL   Mol. Metab. 8:144-157(2018).
//
RX   PubMed=30251567; DOI=10.1177/0963689718798564; PMCID=PMC6180725;
RA   Pellegrini S., Manenti F., Chimienti R., Nano R., Ottoboni L.,
RA   Ruffini F., Martino G., Ravassard P., Piemonti L., Sordi V.;
RT   "Differentiation of Sendai virus-reprogrammed iPSC into beta cells,
RT   compared with human pancreatic islets and immortalized beta cell
RT   line.";
RL   Cell Transplant. 27:1548-1560(2018).
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RX   PubMed=31976379; DOI=10.12688/wellcomeopenres.15447.2; PMCID=PMC6961417;
RA   Grotz A.K., Abaitua F., Navarro-Guerrero E., Hastoy B., Ebner D.,
RA   Gloyn A.L.;
RT   "A CRISPR/Cas9 genome editing pipeline in the EndoC-betaH1 cell line
RT   to study genes implicated in beta cell function.";
RL   Wellcome Open Res. 4:150-150(2019).
//