ID   1E8 [Human leukemia]
AC   CVCL_L811
DR   BioSample; SAMN06481104
DR   cancercelllines; CVCL_L811
DR   Wikidata; Q54582833
RX   PubMed=7528218;
RX   PubMed=20143388;
CC   Problematic cell line: Contaminated. Parent cell line (BLIN-1) has been shown to be a NALM-6 derivative (PubMed=20143388).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00169.
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; 50800; DUX4 + HGNC; 5477; IGH; Name(s)=IGH-DUX4; Note=The translocation occurs in the silenced IGH allele (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Arg1068Ter (c.3202C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Ala146Thr (c.436G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9864; RARA; Simple; p.Gln45Ter (c.133C>T); ClinVar=VCV000393019; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9143; Adult B acute lymphoblastic leukemia
DI   ORDO; Orphanet_99860; Precursor B-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_8173 ! BLIN-1
SX   Male
AG   19Y
CA   Cancer cell line
DT   Created: 06-05-13; Last updated: 30-01-24; Version: 25
RX   PubMed=7528218; DOI=10.1016/S0021-9258(18)31664-8;
RA   Weng W.-K., Jarvis L., LeBien T.W.;
RT   "Signaling through CD19 activates Vav/mitogen-activated protein kinase
RT   pathway and induces formation of a CD19/Vav/phosphatidylinositol
RT   3-kinase complex in human B cell precursors.";
RL   J. Biol. Chem. 269:32514-32521(1994).
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).