ID   TI-1 [Human leukemia]
AC   CVCL_L806
DR   BioSample; SAMN03151817
DR   Wikidata; Q54972401
RX   PubMed=1611097;
RX   PubMed=11871388;
RX   PubMed=12592342;
RX   PubMed=20143388;
CC   Problematic cell line: Contaminated. Shown to be a K-562 derivative (PubMed=11871388; PubMed=12592342; PubMed=20143388).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00278.
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
CC   Derived from sampling site: Pleural effusion.
DI   NCIt; C9110; Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0004 ! K-562
SX   Female
AG   53Y
CA   Cancer cell line
DT   Created: 06-05-13; Last updated: 21-03-23; Version: 22
RX   PubMed=1611097; DOI=10.1182/blood.V80.1.46.46;
RA   Taoka T., Tasaka T., Tanaka T., Irino S., Norman A.W.;
RT   "Characterization, growth, and differentiation of a human myeloid
RT   leukemia cell line, TI-1 cell.";
RL   Blood 80:46-52(1992).
RX   PubMed=11871388; DOI=10.1182/blood.V99.5.1874;
RA   Rush L.J., Heinonen K., Mrozek K., Wolf B.J., Abdel-Rahman M.,
RA   Szymanska J., Peltomaki P., Kapadia F., Bloomfield C.D.,
RA   Caligiuri M.A., Plass C.;
RT   "Comprehensive cytogenetic and molecular genetic characterization of
RT   the TI-1 acute myeloid leukemia cell line reveals cross-contamination
RT   with K-562 cell line.";
RL   Blood 99:1874-1876(2002).
RX   PubMed=12592342; DOI=10.1038/sj.leu.2402799;
RA   Drexler H.G., Dirks W.G., Matsuo Y., MacLeod R.A.F.;
RT   "False leukemia-lymphoma cell lines: an update on over 500 cell
RT   lines.";
RL   Leukemia 17:416-426(2003).
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).