ID   AG04059
AC   CVCL_L623
SY   AG-4059; AG 4059; AG04059B; GRC#0179
DR   CLO; CLO_0034766
DR   Coriell; AG04059
DR   GEO; GSM3124624
DR   Wikidata; Q54609911
RX   CelloPub=CLPUB00597;
RX   PubMed=3374507;
RX   PubMed=6223188;
RX   PubMed=6538202;
RX   PubMed=7176709;
RX   PubMed=7307581;
RX   PubMed=10741968;
RX   PubMed=30567591;
CC   Part of: Baltimore Longitudinal Study of Aging (BLSA) cell line collection.
CC   Population: Caucasian.
CC   Doubling time: Slow growth (Coriell=AG04059).
CC   Karyotypic information: 46,XY [94%]; 45,X [6%] (Coriell=AG04059).
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Arm, skin; UBERON=UBERON_0002427.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   96Y
CA   Finite cell line
DT   Created: 06-05-13; Last updated: 29-06-23; Version: 15
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RX   CelloPub=CLPUB00597;
RG   National Institute on Aging;
RT   "1994 catalog of cell lines. NIA Aging Cell Repository.";
RL   (In) Institute for Medical Research (Camden, N.J.); pp.1-351; National Institutes of Health; Bethesda (1994).
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RX   PubMed=3374507; DOI=10.1016/0027-5107(88)90211-4;
RA   Azzarone B., Chaponnier C., Krief P., Mareel M.M., Suarez H.G.,
RA   Macieira-Coelho A.;
RT   "Human fibroblasts from cancer patients: lifespan and transformed
RT   phenotype in vitro and role of mesenchyme in vivo.";
RL   Mutat. Res. 199:313-325(1988).
//
RX   PubMed=6223188; DOI=10.1016/0047-6374(83)90071-4;
RA   Chapman M.L., Zaun M.R., Gracy R.W.;
RT   "Changes in NAD levels in human lymphocytes and fibroblasts during
RT   aging and in premature aging syndromes.";
RL   Mech. Ageing Dev. 21:157-167(1983).
//
RX   PubMed=6538202; DOI=10.1083/jcb.98.3.1133;
RA   Azzarone B., Suarez H.G., Mingari M.C., Moretta L., Fauci A.S.;
RT   "4F2 monoclonal antibody recognizes a surface antigen on spread human
RT   fibroblasts of embryonic but not of adult origin.";
RL   J. Cell Biol. 98:1133-1137(1984).
//
RX   PubMed=7176709; DOI=10.1016/0047-6374(82)90061-6;
RA   Tollefsbol T.O., Zaun M.R., Gracy R.W.;
RT   "Increased lability of triosephosphate isomerase in progeria and
RT   Werner's syndrome fibroblasts.";
RL   Mech. Ageing Dev. 20:93-101(1982).
//
RX   PubMed=7307581; DOI=10.1159/000131624;
RA   Schneider E.L., Monticone R., Smith J., Braunschweiger K.I., Roberts T.;
RT   "Skin fibroblast cultures derived from members of the Baltimore
RT   longitudinal study: a new resource for studies of cellular aging.";
RL   Cytogenet. Cell Genet. 31:40-46(1981).
//
RX   PubMed=10741968; DOI=10.1126/science.287.5462.2486;
RA   Ly D.H., Lockhart D.J., Lerner R.A., Schultz P.G.;
RT   "Mitotic misregulation and human aging.";
RL   Science 287:2486-2492(2000).
//
RX   PubMed=30567591; DOI=10.1186/s13059-018-1599-6;
RA   Fleischer J.G., Schulte R., Tsai H.H., Tyagi S., Ibarra A.,
RA   Shokhirev M.N., Huang L., Hetzer M.W., Navlakha S.;
RT   "Predicting age from the transcriptome of human dermal fibroblasts.";
RL   Genome Biol. 19:221.1-221.8(2018).
//