ID   Rh3
AC   CVCL_L415
AS   CVCL_A461
SY   RH3; Rh-3; SJRH-3; SJRH3
DR   BTO; BTO:0005383
DR   Cell_Model_Passport; SIDM01334
DR   Cosmic; 687956
DR   Cosmic; 1097743
DR   Cosmic; 1104558
DR   Cosmic; 1108741
DR   Cosmic; 2820090
DR   Wikidata; Q54950338
RX   PubMed=7536457;
RX   PubMed=8275086;
RX   PubMed=9823299;
RX   PubMed=23665679;
RX   PubMed=23882450;
CC   Sequence variation: Gene fusion; HGNC; 3819; FOXO1 + HGNC; 8617; PAX3; Name(s)=PAX3-FOXO1, PAX3-FKHR (PubMed=7536457; PubMed=8275086).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: Metastatic; Axillary lymph node; UBERON=UBERON_0001097.
DI   NCIt; C3749; Alveolar rhabdomyosarcoma
DI   ORDO; Orphanet_99756; Alveolar rhabdomyosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_8752 ! Rh28
SX   Male
AG   17Y
CA   Cancer cell line
DT   Created: 06-05-13; Last updated: 29-06-23; Version: 16
//
RX   PubMed=7536457; DOI=10.1002/gcc.2870120305;
RA   Biegel J.A., Nycum L.M., Valentine V.A., Barr F.G., Shapiro D.N.;
RT   "Detection of the t(2;13)(q35;q14) and PAX3-FKHR fusion in alveolar
RT   rhabdomyosarcoma by fluorescence in situ hybridization.";
RL   Genes Chromosomes Cancer 12:186-192(1995).
//
RX   PubMed=8275086; DOI=10.1038/ng1193-230;
RA   Galili N., Davis R.J., Fredericks W.J., Mukhopadhyay S.,
RA   Rauscher F.J. 3rd, Emanuel B.S., Rovera G., Barr F.G.;
RT   "Fusion of a fork head domain gene to PAX3 in the solid tumour
RT   alveolar rhabdomyosarcoma.";
RL   Nat. Genet. 5:230-235(1993).
//
RX   PubMed=9823299;
RA   Khan J., Simon R.M., Bittner M., Chen Y.-D., Leighton S.B., Pohida T.,
RA   Smith P.D., Jiang Y., Gooden G.C., Trent J.M., Meltzer P.S.;
RT   "Gene expression profiling of alveolar rhabdomyosarcoma with cDNA
RT   microarrays.";
RL   Cancer Res. 58:5009-5013(1998).
//
RX   PubMed=23665679; DOI=10.1038/onc.2013.129;
RA   Sokolowski E., Turina C.B., Kikuchi K., Langenau D.M., Keller C.;
RT   "Proof-of-concept rare cancers in drug development: the case for
RT   rhabdomyosarcoma.";
RL   Oncogene 33:1877-1889(2014).
//
RX   PubMed=23882450; DOI=10.3389/fonc.2013.00183; PMCID=PMC3713458;
RA   Hinson A.R.P., Jones R., Crose L.E.S., Belyea B.C., Barr F.G.,
RA   Linardic C.M.;
RT   "Human rhabdomyosarcoma cell lines for rhabdomyosarcoma research:
RT   utility and pitfalls.";
RL   Front. Oncol. 3:183.1-183.12(2013).
//