Cellosaurus cell line OKF4/TERT-1 (CVCL

Cellosaurus OKF4/TERT-1 (CVCL_L227)

Cross-references
Cell line name	OKF4/TERT-1
Synonyms	OKF4 TERT; OKF4/TERT
Accession	CVCL_L227
Resource Identification Initiative	To cite this cell line use: OKF4/TERT-1 (RRID:CVCL_L227)
Comments	Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT. Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR). Omics: Array-based CGH. Omics: CNV analysis. Omics: Transcriptome analysis by microarray. Derived from site: In situ; Oral cavity, floor of mouth; UBERON=UBERON_0003679. Cell type: Keratinocyte; CL=CL_0000312.
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_L220 (OKF4)
Sex of cell	Male
Age at sampling	28Y
Category	Telomerase immortalized cell line
Web pages	https://dermatology.bwh.harvard.edu/docs/Cell-Culture-Core-Cell-Lines.pdf
Publications	PubMed=10648628; DOI=10.1128/mcb.20.4.1436-1447.2000; PMCID=PMC85304 Dickson M.A., Hahn W.C., Ino Y., Ronfard V., Wu J.Y., Weinberg R.A., Louis D.N., Li F.P., Rheinwald J.G. Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Mol. Cell. Biol. 20:1436-1447(2000) PubMed=12077343; DOI=10.1128/mcb.22.14.5157-5172.2002; PMCID=PMC139780 Rheinwald J.G., Hahn W.C., Ramsey M.R., Wu J.Y., Guo Z.-Y., Tsao H., De Luca M., Catricala C., O'Toole K.M. A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status. Mol. Cell. Biol. 22:5157-5172(2002) PubMed=25169794; DOI=10.1111/jop.12236 Dickman C.T.D., Towle R., Saini R., Garnis C. Molecular characterization of immortalized normal and dysplastic oral cell lines. J. Oral Pathol. Med. 44:329-336(2015)
Encyclopedic resources	Wikidata; Q54931919
Gene expression databases	GEO; GSM1431131
Entry history
Entry creation	06-May-2013
Last entry update	19-Dec-2024
Version number	15