Cellosaurus logo
expasy logo

Cellosaurus TLBR-1 (CVCL_L177)

[Text version]
Cell line name TLBR-1
Synonyms TLBR 1; TLBR1; T-cell Lymphoma BReast-1
Accession CVCL_L177
Resource Identification Initiative To cite this cell line use: TLBR-1 (RRID:CVCL_L177)
Comments Doubling time: 55 hours (PubMed=21425149); ~30-40 hours (DSMZ=ACC-904).
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:11364; STAT3; Simple; p.Ser614Arg (c.1842C>G); Zygosity=Unspecified (PubMed=28356514).
Disease Anaplastic large cell lymphoma, ALK-negative (NCIt: C37194)
ALK-negative anaplastic large cell lymphoma (ORDO: Orphanet_300903)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 42Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3027; DSMZ=ACC-904

Markers:
AmelogeninX
CSF1PO10,11
D2S133817,26
D3S135817,18
D5S81811,13 (ATCC=CRL-3027)
11,13,14 (DSMZ=ACC-904)
D7S8208,10
D8S117912,13
D13S31711,14
D16S53912
D18S5113,14
D19S43313,14
D21S1128,29,30
FGA22,24
Penta D10,11
Penta E14,19
TH017,9
TPOX8
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=21425149; DOI=10.1002/cncr.25654; PMCID=PMC4175713
Lechner M.G., Lade S., Liebertz D.J., Prince H.M., Brody G.S., Webster H.R., Epstein A.L.
Breast implant-associated, ALK-negative, T-cell, anaplastic, large-cell lymphoma: establishment and characterization of a model cell line (TLBR-1) for this newly emerging clinical entity.
Cancer 117:1478-1489(2011)

PubMed=22791880; DOI=10.1158/1078-0432.CCR-12-0101
Lechner M.G., Megiel C., Church C.H., Angell T.E., Russell S.M., Sevell R.B., Jang J.K., Brody G.S., Epstein A.L.
Survival signals and targets for therapy in breast implant-associated ALK -- anaplastic large cell lymphoma.
Clin. Cancer Res. 18:4549-4559(2012)

PubMed=28356514; DOI=10.1073/pnas.1700682114; PMCID=PMC5393253
Chen J., Zhang Y., Petrus M.N., Xiao W.-M., Nicolae A., Raffeld M., Pittaluga S., Bamford R.N., Nakagawa M., Ouyang S.T.-Y., Epstein A.L., Kadin M.E., Del Mistro A., Woessner R.D., Jaffe E.S., Waldmann T.A.
Cytokine receptor signaling is required for the survival of ALK- anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations.
Proc. Natl. Acad. Sci. U.S.A. 114:3975-3980(2017)

Cross-references
Cell line collections (Providers) ATCC; CRL-3027 - Discontinued
DSMZ; ACC-904
Cell line databases/resources DSMZCellDive; ACC-904
Encyclopedic resources Wikidata; Q54972607
Gene expression databases GEO; GSM2527949
Polymorphism and mutation databases Cosmic; 2814460
Entry history
Entry creation06-May-2013
Last entry update19-Dec-2024
Version number16