Cellosaurus PathHunter CHO-K1 SSTR2 Activated GPCR Internalization (CVCL_KZ11)
| Cell line name | PathHunter CHO-K1 SSTR2 Activated GPCR Internalization |
|---|---|
| Synonyms | PathHunter SSTR2 Activated GPCR Internalization CHO-K1 |
| Accession | CVCL_KZ11 |
| Resource Identification Initiative | To cite this cell line use: PathHunter CHO-K1 SSTR2 Activated GPCR Internalization (RRID:CVCL_KZ11) |
| Comments | Characteristics: PathHunter activated GPCR internalization cell lines co-express an untagged GPCR, a beta-arrestin tagged with a beta-galactosidase fragment (Enzyme Acceptor=EA) and a second beta-galactosidase fragment (ProLink=PK) localized to the endosomes. Beta-arrestin recruitment is followed by internalization of the GPCR/arrestin-EA complex in PK-tagged endosomes and allowing complementation of the PK and EA enzyme fragments thus resulting into a catalytically active enzyme that generate a chemiluminescent signal. Genetic integration: Method=Transfection; Gene=HGNC; 11331; SSTR2. Genetic integration: Method=Transfection; Gene=HGNC; 712; ARRB2. Derived from site: In situ; Ovary; UBERON=UBERON_0000992. Cell type: Epithelial cell of ovary; CL=CL_2000064. |
| Species of origin | Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029) |
| Hierarchy | Parent: CVCL_0214 (CHO-K1) |
| Sex of cell | Female |
| Age at sampling | Adult |
| Category | Spontaneously immortalized cell line |
| Cross-references | |
| Cell line collections (Providers) | DiscoverX; 93-0676C2 |
| Encyclopedic resources | Wikidata; Q54937980 |
| Entry history | |
| Entry creation | 22-Aug-2017 |
| Last entry update | 10-Sep-2024 |
| Version number | 8 |