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Cellosaurus T-47D Tet-Off (CVCL_KU40)

[Text version]
Cell line name T-47D Tet-Off
Accession CVCL_KU40
Resource Identification Initiative To cite this cell line use: T-47D Tet-Off (RRID:CVCL_KU40)
Comments Population: Caucasian.
Characteristics: Transfected with the tetracycline transactivator (tTA) protein, a fusion of tetR with the activation domain of HSV-1 VP16.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (Note=With p.Met1_Arg360del).
Discontinued: Takara/Clontech; Catalog number 630924.
Discontinued: Takara/Clontech; Catalog number 631145.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Leu194Phe (c.580C>T); ClinVar=VCV000127817; Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0553 (T-47D)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
Cross-references
Cell line databases/resources cancercelllines; CVCL_KU40
Encyclopedic resources Wikidata; Q54971345
Entry history
Entry creation22-Aug-2017
Last entry update10-Sep-2024
Version number13