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Cellosaurus HepG2 Tet-On Advanced (CVCL_KT01)

[Text version]
Cell line name HepG2 Tet-On Advanced
Accession CVCL_KT01
Resource Identification Initiative To cite this cell line use: HepG2 Tet-On Advanced (RRID:CVCL_KT01)
Comments Population: Caucasian.
Characteristics: Transfected with an advanced reverse tetracycline-controlled transactivator (rtTA2(S)-M2), a fusion between a mutated version of E.coli TetR and the activating domain of HSV-1 VP16.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (Note=With p.Met1_Arg360del).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Web pages http://www.clontech.com/US/Products/Inducible_Systems/Tetracycline-Inducible_Expression/ibcGetAttachment.jsp?cItemId=26901
Cross-references
Cell line databases/resources cancercelllines; CVCL_KT01
Encyclopedic resources Wikidata; Q54882848
Entry history
Entry creation22-Aug-2017
Last entry update10-Sep-2024
Version number15