Cellosaurus logo
expasy logo

Cellosaurus K562/NFAT-luc (CVCL_KS44)

[Text version]
Cell line name K562/NFAT-luc
Accession CVCL_KS44
Resource Identification Initiative To cite this cell line use: K562/NFAT-luc (RRID:CVCL_KS44)
Comments Population: Caucasian.
Characteristics: The luciferase reporter gene is under the control of multiple copies of the NFAT response element (PubMed=16834536).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transfection; Gene=UniProtKB; P08659; Firefly luciferase.
Discontinued: Thermofisher/Panomics; Catalog number RC0009.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=16834536; DOI=10.1089/adt.2006.4.307
Lai C.-F., Jiang X., Li X.-Q.
Development of luciferase reporter-based cell assays.
Assay Drug Dev. Technol. 4:307-315(2006)

Cross-references
Encyclopedic resources Wikidata; Q54899415
Entry history
Entry creation22-Aug-2017
Last entry update19-Dec-2024
Version number17