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Cellosaurus A549/NFkB-luc (CVCL_KS36)

[Text version]
Cell line name A549/NFkB-luc
Accession CVCL_KS36
Resource Identification Initiative To cite this cell line use: A549/NFkB-luc (RRID:CVCL_KS36)
Comments Population: Caucasian.
Characteristics: The luciferase reporter gene is under the control of multiple copies of the NF-kappaB response element (PubMed=16834536).
Genetic integration: Method=Transfection; Gene=UniProtKB; P08659; Firefly luciferase.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Discontinued: Thermofisher/Panomics; Catalog number RC0002.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=16834536; DOI=10.1089/adt.2006.4.307
Lai C.-F., Jiang X., Li X.-Q.
Development of luciferase reporter-based cell assays.
Assay Drug Dev. Technol. 4:307-315(2006)

Cross-references
Cell line databases/resources cancercelllines; CVCL_KS36
Encyclopedic resources Wikidata; Q54607050
Entry history
Entry creation22-Aug-2017
Last entry update19-Dec-2024
Version number14