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Cellosaurus CellSensor SBE-bla A375 (CVCL_KS16)

[Text version]
Cell line name CellSensor SBE-bla A375
Synonyms SBE-bla A375
Accession CVCL_KS16
Resource Identification Initiative To cite this cell line use: CellSensor SBE-bla A375 (RRID:CVCL_KS16)
Comments Population: Caucasian.
Characteristics: Transfected with a plasmid containing a beta-lactamase reporter gene under control of a Smad binding element (SBE).
Genetic integration: Method=Transfection; Gene=UniProtKB; P62593; Escherichia coli beta-lactamase bla (Note=With p.Met1_Phe22del, p.Ala23Met, p.Val82Ile and p.Met184Val).
Genetic integration: Method=Transfection; Gene=UniProtKB; P0C2P0; Aspergillus terreus blasticidin-S deaminase (Bsd).
Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0132 (A-375)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
Web pages https://www.thermofisher.com/order/catalog/product/K1514
Cross-references
Cell line databases/resources cancercelllines; CVCL_KS16
Encyclopedic resources Wikidata; Q54809230
Entry history
Entry creation22-Aug-2017
Last entry update10-Sep-2024
Version number15