ID   U87MG.DY3
AC   CVCL_JY82
SY   U87/DY3
DR   cancercelllines; CVCL_JY82
DR   Wikidata; Q54973773
RX   PubMed=8810340;
CC   Problematic cell line: Misidentified. Parent cell line (U-87MG ATCC) is not the original glioblastoma cell line established in 1968 at the University of Uppsala.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 7765; NF1; Simple; p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT); ClinVar=VCV000420078; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; c.209+1G>T; ClinVar=VCV000229705; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Transfected with: HGNC; 3236; EGFR (with p.Val30_Arg297del, p.Tyr1092Phe, p.Tyr1172Phe and p.Tyr1197Phe = EGFRvIII and 3 TyrP site dead).
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0022 ! U-87MG ATCC
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 22-08-17; Last updated: 05-10-23; Version: 10
//
RX   PubMed=8810340; DOI=10.1074/jbc.271.41.25639;
RA   Prigent S.A., Nagane M., Lin H., Huvar I., Boss G.R., Feramisco J.R.,
RA   Cavenee W.K., Huang H.-J.S.;
RT   "Enhanced tumorigenic behavior of glioblastoma cells expressing a
RT   truncated epidermal growth factor receptor is mediated through the
RT   Ras-Shc-Grb2 pathway.";
RL   J. Biol. Chem. 271:25639-25645(1996).
//