ID   AR300
AC   CVCL_JY57
DR   Wikidata; Q54750359
RX   PubMed=3021747;
RX   PubMed=8389452;
CC   Selected for resistance to: ChEBI; CHEBI_138016; 5-(N-methyl-N-propyl)amiloride (MPA).
CC   Sequence variation: Mutation; UniProtKB; P48761; Slc9a1; Simple; p.Leu167Phe (c.499C>T); Zygosity=Homozygous (PubMed=8389452).
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
CC   Cell type: Fibroblast of lung; CL=CL_0002553.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_JY56 ! AR40
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 22-08-17; Last updated: 19-12-24; Version: 9
//
RX   PubMed=3021747; DOI=10.1016/S0021-9258(18)66915-7;
RA   Franchi A., Cragoe E.J. Jr., Pouyssegur J.;
RT   "Isolation and properties of fibroblast mutants overexpressing an
RT   altered Na+/H+ antiporter.";
RL   J. Biol. Chem. 261:14614-14620(1986).
//
RX   PubMed=8389452; DOI=10.1073/pnas.90.10.4508; PMCID=PMC46541;
RA   Counillon L., Franchi A., Pouyssegur J.;
RT   "A point mutation of the Na+/H+ exchanger gene (NHE1) and
RT   amplification of the mutated allele confer amiloride resistance upon
RT   chronic acidosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:4508-4512(1993).
//