Cellosaurus cell line 14433_1 (CVCL

Cellosaurus 14433_1 (CVCL_JY31)

[Text version]

Cell line name

14433_1

Synonyms

14433

Accession

CVCL_JY31

Resource Identification Initiative

To cite this cell line use: 14433_1 (RRID:CVCL_JY31)

Comments

Doubling time: 2-3 days (PubMed=25862976).
Omics: Genome sequenced (low read coverage).
Omics: Transcriptome analysis by RNAseq.
Miscellaneous: Age at sampling and TP53 mutation cDNA coordinates from personal communication of Castillo-Tong, Dan Cacsire.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.

Sequence variations

Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Lys2853Ter (c.8557A>T); ClinVar=VCV000372573; Zygosity=Homozygous (PubMed=25862976; PubMed=31150822).
Mutation; HGNC; HGNC:11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Unspecified; Note=Splice donor mutation (PubMed=25862976; PubMed=31150822).

Disease

High grade ovarian serous adenocarcinoma (NCIt: C105555)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

61Y

Category

Cancer cell line

STR profile

Source(s): PubMed=31150822

Markers:

Amelogenin	X
CSF1PO	10,11
D1S1656	12,19.3
D2S1338	22
D3S1358	15
D5S818	11,12
D6S1043	20
D7S820	8,10
D8S1179	14,15
D12S391	21
D13S317	11
D16S539	12
D18S51	18
D19S433	14,15
D21S11	29,30
FGA	21
Penta D	9,10
Penta E	14
TH01	8
TPOX	10,11
vWA	17

Publications

PubMed=25862976; DOI=10.1016/j.canlet.2015.03.040
Kreuzinger C., Gamperl M., Wolf A., Heinze G., Geroldinger A., Lambrechts D., Boeckx B., Smeets D., Horvat R., Aust S., Hamilton G., Zeillinger R., Castillo-Tong D.C.
Molecular characterization of 7 new established cell lines from high grade serous ovarian cancer.
Cancer Lett. 362:218-228(2015)

PubMed=31150822; DOI=10.1016/j.canlet.2019.05.032
Kreuzinger C., von der Decken I., Wolf A., Gamperl M., Koller J., Karacs J., Pfaffinger S., Bartl T., Reinthaller A., Grimm C., Singer C.F., Braicu E.I., Cunnea P., Gourley C., Smeets D., Boeckx B., Lambrechts D., Perco P., Horvat R., Berns E.M.J.J., Castillo-Tong D.C.
Patient-derived cell line models revealed therapeutic targets and molecular mechanisms underlying disease progression of high grade serous ovarian cancer.
Cancer Lett. 459:1-12(2019)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_JY31

Encyclopedic resources

Wikidata; Q54581913

Entry history

Entry creation

22-Aug-2017

Last entry update

19-Dec-2024

Version number