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Cellosaurus NCI-hTERT-CL6 (CVCL_JY26)

[Text version]
Cell line name NCI-hTERT-CL6
Accession CVCL_JY26
Resource Identification Initiative To cite this cell line use: NCI-hTERT-CL6 (RRID:CVCL_JY26)
Comments Characteristics: Overexpresses TERT; compared to the parent cell line, it has better adhesion properties, ability to be maintained in culture for longer periods after confluency and is more efficient in mucins MUC1, MUC2 and MUC13 secretion (PubMed=26074691).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Gene deletion; HGNC; HGNC:6770; SMAD4; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3431; ERBB3; Simple; p.Thr757Lys (c.2270C>A); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Gastric tubular adenocarcinoma (NCIt: C5473)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1603 (NCI-N87)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=26074691; DOI=10.3748/wjg.v21.i21.6526; PMCID=PMC4458763
Saraiva-Pava K., Navabi N., Skoog E.C., Linden S.K., Oleastro M., Roxo-Rosa M.
New NCI-N87-derived human gastric epithelial line after human telomerase catalytic subunit over-expression.
World J. Gastroenterol. 21:6526-6542(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_JY26
Encyclopedic resources Wikidata; Q54908204
Entry history
Entry creation22-Aug-2017
Last entry update19-Dec-2024
Version number16