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Cellosaurus LdlF (CVCL_JY00)

[Text version]
Cell line name LdlF
Synonyms ldlF; CHO ldlF
Accession CVCL_JY00
Resource Identification Initiative To cite this cell line use: LdlF (RRID:CVCL_JY00)
Comments Characteristics: At the non-permissive temperature of 39.5 Celsius exhibits rapid degradation of LDLRs, disruption of ER-through Golgi transport and disintegration of the Golgi apparatus.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Sequence variations
  • Mutation; UniProtKB; Q60445; Cope; Simple; p.Glu251Lys (c.751C>T); Zygosity=Homozygous (PubMed=8626666).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_0214 (CHO-K1)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=8063714; DOI=10.1016/S0021-9258(17)31915-4
Hobbie L., Fisher A.S., Lee S., Flint A., Krieger M.
Isolation of three classes of conditional lethal Chinese hamster ovary cell mutants with temperature-dependent defects in low density lipoprotein receptor stability and intracellular membrane transport.
J. Biol. Chem. 269:20958-20970(1994)

PubMed=8207054; DOI=10.1083/jcb.125.6.1213; PMCID=PMC2290926
Guo Q., Vasile E., Krieger M.
Disruptions in Golgi structure and membrane traffic in a conditional lethal mammalian cell mutant are corrected by epsilon-COP.
J. Cell Biol. 125:1213-1224(1994)

PubMed=8626666; DOI=10.1074/jbc.271.19.11191
Guo Q., Penman M., Trigatti B.L., Krieger M.
A single point mutation in epsilon-COP results in temperature-sensitive, lethal defects in membrane transport in a Chinese hamster ovary cell mutant.
J. Biol. Chem. 271:11191-11196(1996)

Cross-references
Encyclopedic resources Wikidata; Q54902385
Entry history
Entry creation22-Aug-2017
Last entry update30-Jan-2024
Version number12