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Cellosaurus MCF-10A TP53(-/-) (CVCL_JM25)

[Text version]
Cell line name MCF-10A TP53(-/-)
Synonyms TP53 (-/-) MCF10A
Accession CVCL_JM25
Resource Identification Initiative To cite this cell line use: MCF-10A TP53(-/-) (RRID:CVCL_JM25)
Comments Knockout cell: Method=Homologous recombination; HGNC; HGNC:11998; TP53.
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0598 (MCF-10A)
Sex of cell Female
Age at sampling 36Y
Category Spontaneously immortalized cell line
Publications

PubMed=20562907; DOI=10.1038/onc.2010.220; PMCID=PMC3164558
Weiss M.B., Vitolo M.I., Mohseni M., Rosen D.M., Denmeade S.R., Park B.H., Weber D.J., Bachman K.E.
Deletion of p53 in human mammary epithelial cells causes chromosomal instability and altered therapeutic response.
Oncogene 29:4715-4724(2010)

Cross-references
Cell line collections (Providers) Horizon_Discovery; HD+101-005
Encyclopedic resources Wikidata; Q54904293
Entry history
Entry creation15-May-2017
Last entry update19-Dec-2024
Version number12