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Cellosaurus AT-2 (CVCL_JK53)

[Text version]
Cell line name AT-2
Accession CVCL_JK53
Resource Identification Initiative To cite this cell line use: AT-2 (RRID:CVCL_JK53)
Comments Characteristics: From transgenic mice expressing a fusion gene comprised of the rat alpha-cardiac myosin heavy chain promoter and the SV40 early region (MHC-TAG).
Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; SV40 large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Heart; UBERON=UBERON_0000948.
Cell type: Cardiomyocyte; CL=CL_0002495.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C3HeB/FeJ transgenic.
Age at sampling Age unspecified
Category Transformed cell line
Publications

PubMed=1377879; DOI=10.1152/ajpheart.1992.262.6.H1867
Katz E.B., Steinhelper M.E., Delcarpio J.B., Daud A.I., Claycomb W.C., Field L.J.
Cardiomyocyte proliferation in mice expressing alpha-cardiac myosin heavy chain-SV40 T-antigen transgenes.
Am. J. Physiol. 262:H1867-H1876(1992)

PubMed=8498581; DOI=10.1152/ajpheart.1993.264.5.H1693
Daud A.I., Lanson N.A. Jr., Claycomb W.C., Field L.J.
Identification of SV40 large T-antigen-associated proteins in cardiomyocytes from transgenic mice.
Am. J. Physiol. 264:H1693-H1700(1993)

PubMed=10908350; DOI=10.1093/nar/28.15.2882; PMCID=PMC102680
Lanson N.A. Jr., Egeland D.B., Royals B.A., Claycomb W.C.
The MRE11-NBS1-RAD50 pathway is perturbed in SV40 large T antigen-immortalized AT-1, AT-2 and HL-1 cardiomyocytes.
Nucleic Acids Res. 28:2882-2892(2000)

Cross-references
Encyclopedic resources Wikidata; Q54750828
Entry history
Entry creation15-May-2017
Last entry update10-Sep-2024
Version number10