ID   S462.TY
AC   CVCL_JK02
SY   S462-TY; S462TY
DR   cancercelllines; CVCL_JK02
DR   Wikidata; Q54951929
RX   PubMed=18281493;
RX   PubMed=28469964;
CC   Characteristics: Was created by passage of S462 as xenografts.
CC   Sequence variation: Gene deletion; HGNC; HGNC:7765; NF1; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7765; NF1; Simple; p.Tyr2285Ter (c.6792C>A); ClinVar=VCV000185082; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg110Pro (c.329G>C); ClinVar=VCV000233627; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Thigh; UBERON=UBERON_0000376.
DI   NCIt; C3798; Malignant peripheral nerve sheath tumor
DI   NCIt; C3273; Neurofibromatosis type 1
DI   ORDO; Orphanet_3148; Malignant peripheral nerve sheath tumor
DI   ORDO; Orphanet_636; Neurofibromatosis type 1
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1Y70 ! S462
SX   Female
AG   19Y
CA   Cancer cell line
DT   Created: 15-05-17; Last updated: 19-12-24; Version: 12
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RX   PubMed=18281493; DOI=10.1158/0008-5472.CAN-07-2734; PMCID=PMC2855837;
RA   Mahller Y.Y., Vaikunth S.S., Ripberger M.C., Baird W.H., Saeki Y.,
RA   Cancelas J.A., Crombleholme T.M., Cripe T.P.;
RT   "Tissue inhibitor of metalloproteinase-3 via oncolytic herpesvirus
RT   inhibits tumor growth and vascular progenitors.";
RL   Cancer Res. 68:1170-1179(2008).
//
RX   PubMed=28469964; PMCID=PMC5411799;
RA   Guo J.-M., Grovola M.R., Xie H., Coggins G.E., Duggan P., Hasan R.,
RA   Huang J.-L., Lin D.W., Song C., Witek G.M., Berritt S., Schultz D.C.,
RA   Field J.;
RT   "Comprehensive pharmacological profiling of neurofibromatosis cell
RT   lines.";
RL   Am. J. Cancer Res. 7:923-934(2017).
//