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Cellosaurus POLZ Y2779F-POLH+/- (CVCL_JG99)

[Text version]
Cell line name POLZ Y2779F-POLH+/-
Synonyms Nalm-6-MSH+/TK+/-/POLH+/-/REV3L Y2779F
Accession CVCL_JG99
Resource Identification Initiative To cite this cell line use: POLZ Y2779F-POLH+/- (RRID:CVCL_JG99)
Comments Population: Caucasian.
Knockout cell: Method=Homologous recombination; HGNC; HGNC:9181; POLH (Note=1 of 2 alleles).
Knockout cell: Method=Homologous recombination; HGNC; HGNC:11830; TK1 (Note=1 of 2 alleles).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:7325; MSH2 (Note=Exons 9 to 16).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:50800; DUX4 + HGNC; HGNC:5477; IGH; Name(s)=IGH-DUX4; Note=The translocation occurs in the silenced IGH allele (from parent cell line).
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Arg1068Ter (c.3202C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Ala146Thr (c.436G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9864; RARA; Simple; p.Gln45Ter (c.133C>T); ClinVar=VCV000393019; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9968; REV3L; Simple_edited; p.Tyr2779Phe; Zygosity=Unspecified; Note=By homologous recombination (JCRB=JCRB1527).
Disease Adult B acute lymphoblastic leukemia (NCIt: C9143)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_UD71 (Nalm-6-MSH+/TK+/-)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
STR profile Source(s): JCRB=JCRB1527

Markers:
AmelogeninX,Y
CSF1PO14
D5S81811,12
D7S8208,12
D13S3179,13
D16S5399,11
TH018,9
TPOX8,10
vWA15,16

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Cross-references
Cell line collections (Providers) JCRB; JCRB1527
Cell line databases/resources cancercelllines; CVCL_JG99
Encyclopedic resources Wikidata; Q54947742
Entry history
Entry creation15-May-2017
Last entry update19-Dec-2024
Version number16