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Cellosaurus A-HER2 (CVCL_J973)

[Text version]
Cell line name A-HER2
Synonyms 4D5; NB9644P28
Accession CVCL_J973
Resource Identification Initiative To cite this cell line use: A-HER2 (RRID:CVCL_J973)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-10463.
Biotechnology: The monoclonal antibody produced by this hybridoma was used to prepare the humanized trastuzumab (herceptin) therapeutic antibody.
Monoclonal antibody isotype: IgG1, kappa.
Monoclonal antibody target: UniProtKB; P04626; Human ERBB2/CD340.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Hierarchy Parent: CVCL_4032 (P3X63Ag8.653)
Category Hybridoma
Publications

PubMed=2566907; DOI=10.1128/mcb.9.3.1165-1172.1989; PMCID=PMC362707
Hudziak R.M., Lewis Phillips G.D., Winget M., Fendly B.M., Shepard H.M., Ullrich A.
p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor.
Mol. Cell. Biol. 9:1165-1172(1989)

PubMed=1689212
Fendly B.M., Winget M., Hudziak R.M., Lipari M.T., Napier M.A., Ullrich A.
Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2/neu gene product.
Cancer Res. 50:1550-1558(1990)

Patent=US5677171
Hudziak R.M., Shepard H.M., Ullrich A., Fendly B.M.
Monoclonal antibodies directed to the HER2 receptor.
Patent number US5677171, 14-Oct-1997

Patent=US10280228
Baughman S.A., Shak S.
Treatment with anti-ErbB2 antibodies.
Patent number US10280228, 07-May-2019

Cross-references
Cell line databases/resources CLO; CLO_0001687
Encyclopedic resources Wikidata; Q54606072
Entry history
Entry creation11-Feb-2013
Last entry update21-Mar-2023
Version number9