Cellosaurus cell line MDA 435TR (CVCL

Cross-references
Cell line name	MDA 435TR
Synonyms	MDA 435(TR)
Accession	CVCL_J435
Resource Identification Initiative	To cite this cell line use: MDA 435TR (RRID:CVCL_J435)
Comments	Problematic cell line: Contaminated. Parent cell line (MDA-MB-435) has been shown to be a M14 derivative. Population: Caucasian. Selected for resistance to: ChEBI; CHEBI:45863; Paclitaxel (Taxol). Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072.
Sequence variations	Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line). Mutation; HGNC; 1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
Disease	Amelanotic melanoma (NCIt: C3802)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0417 (MDA-MB-435)
Sex of cell	Male
Age at sampling	33Y
Category	Cancer cell line
Cell line databases/resources	cancercelllines; CVCL_J435
Encyclopedic resources	Wikidata; Q54904548
Entry history
Entry creation	11-Feb-2013
Last entry update	05-Oct-2023
Version number	22