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Cellosaurus RPMI-8226/LR-5 (CVCL_J434)

[Text version]
Cell line name RPMI-8226/LR-5
Synonyms RPMI-8226 LR5; RPMI8226-LR5; RPMI 8226/LR5; 8226/LR-5; 8226/LR5
Accession CVCL_J434
Resource Identification Initiative To cite this cell line use: RPMI-8226/LR-5 (RRID:CVCL_J434)
Comments Characteristics: Produces IgG lambda (from parent cell line).
Selected for resistance to: ChEBI; CHEBI:28876; Melphalan (L-phenylalanine mustard; LPAM; Alkeran).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; 5722; IGKJ4 + HGNC; 5783; IGKV2-28; Name(s)=IGKV2-28-IGKJ4 (from parent cell line).
  • Gene fusion; HGNC; 5865; IGLJ3 + HGNC; 5888; IGLV2-14; Name(s)=IGLV2-14-IGLJ3 (from parent cell line).
  • Mutation; HGNC; 3236; EGFR; Simple; p.Thr751Ile (c.2252C>T); ClinVar=VCV000177773; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Glu285Lys (c.853G>A); ClinVar=VCV000420133; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 12033; TRAF3; Simple; p.Lys191Leufs*60; Zygosity=Unspecified (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0014 (RPMI-8226)
Sex of cell Male
Age at sampling 61Y
Category Cancer cell line

Bellamy W.T., Dalton W.S., Gleason-Guzman M.C., Grogan T.M., Trent J.M.
Development and characterization of a melphalan-resistant human multiple myeloma cell line.
Cancer Res. 51:995-1002(1991)

Encyclopedic resources Wikidata; Q54951248
Gene expression databases GEO; GSM562820
Proteomic databases PRIDE; PXD001276
Entry history
Entry creation11-Feb-2013
Last entry update29-Jun-2023
Version number19